矮小儿童甲状腺功能改变与尿碘关系的探讨

目的:探讨碘摄入与甲状腺功能的关系,以期指导临床合理补碘.方法:2010年1～2月因身材矮小收入我院内分泌科进行相关检查的患儿为研究对象,依据甲状腺功能情况分为3组:亚临床甲减组(SCH组)、临床甲减组(CH组)和甲状腺功能正常组(正常组)；所有病例进行甲状腺功能、晨起空腹尿碘测定等.并对SCH组患儿进行随访.结果:1 689例矮小患儿中,碘摄入不足65例(3.8％),碘过量593例(35.2％),碘摄入正常1031例(61.1％).SCH 105例(6.2％)、CH 23例(1.4％)、正常1 586例(92.4％).105例SCH中,高尿碘78例(74.2％).高尿碘发生率SCH组显著高于CH组和正常组(P＜0.01),SCH组、CH组、正常组尿碘中位数分别为389.38μg/L、136.21 μg/L、221.52μg/L.经过饮食干预和(或)甲状腺素替代治疗3个月后,尿碘均正常7例TSH仍增高.结论:碘摄入过多可能是儿童亚临床甲减的重要原因,尿碘检测应成为儿童常规的检测项目,发现异常及时干预可减少对儿童体格和智力的影响.

Relationship between thyroid function change and urine iodine in short stature children

Objective:To investigate the relation between iodine intake and thyroid function to guide the rational iodine supplement.Methods:The short stature children as the research objects were admitted to the endocrinological department during January 2010 to February 2011 and divided into three groups according to the thyroid function: subclinical hypothyroidism group(SCH),clinical hypothyroidism group(CH) and normal group.The thyroid function and urine iodine were detected in all the research objects.The children...