2011年至2012年988例门诊药品不良反应报告分析

目的：分析门诊患者药品不良反应（ARD）发生的规律及特点，促进临床合理安全用药。方法对医院2011年至2012年门诊药房收集的988例ADR报告进行回顾性统计和分析。结果988例ADR中，女性发生率（57.80%）明显高于男性（42.20%）；ADR涉及12类药物223个品种，发生率最高的为抗感染药物384例（43.32%），其次为抗肿瘤药物128例（15.49%）和中药注射剂108例（13.87%），临床主要表现为皮肤及其附件损害398例（40.28%）和消化系统损害242例（24.49%）。结论应重视ADR报告和监测工作，正确合理地应用药物，为临床合理用药提供参考。

Analysis on 988 Outpatient Cases of ADR in Our Hospital during 2011-2012

Objective To investigate the characteristics and regularity of adverse drug reactions （ ADR ） occurred in outpatients of our hospital for promoting the rational and safe drug use. Methods 988 cases of ADR were collected from outpatients during 2011-2012 and performed the retrospective statistical analysis. Resuts In 988 cases of ADR, the incidence rate in females was 57. 80%, which was significantly higher than 42. 20% in males;ADR involved 12 categories and 223 varieties of drugs. The anti-infective agents had the highest occurrence rate of ADR （ 384 cases, 43. 32% ） , followed by antineoplastic agents （ 128 cases, 15. 49% ） and traditional Chinese medicines （ 108 cases, 13. 87%） . The main clinical manifestations of ADR were lesion of skin and appendant 398 （ 40. 28%） and injury of digestive system 242 （ 24. 49%） . Conclusion The ADR report and monitoring should be highly concerned, drugs should be used cor-rectly and rationally in order to provide reference for clinical rational use of drugs.