他汀类药物对重症急性胰腺炎患者的作用研究

目的：运用彩色多普勒超声观察他汀类药物对重症急性胰腺炎患者的临床作用。方法采用回顾性分析的方法收集2012年6月至2013年5月收治的重症急性胰腺炎患者97例的临床资料，根据既往是否长期服用过他汀类药物分为他汀用药组（试验组）和非他汀用药组（对照组）。运用彩色多普勒超声观察胰腺的影像学情况进行分析，观察2组患者的胰腺大小、形态、边缘，内部回声的改变及胰腺周围、盆腹腔、胸腔有无积液及积液的分布情况。结果入院1d超声显示，2组的胰腺实质回声减低、不均，被膜模糊，胰周及腹腔积液发生率无明显差异；治疗7，14 d后，试验组超声示实质回声改变、被膜模糊发生率均明显小于对照组（ P〈0.05）。入院1 d时，2组患者的胰头、胰体厚度、胰管扩张程度数值无明显差异（ P＞0.05）。治疗7，14 d后，试验组的胰头、胰管扩张程度数值均明显小于对照组（ P〈0.05）；试验组治疗14 d后胰体厚度明显小于对照组（ P〈0.05）。结论他类药物汀对重症急性胰腺炎的炎症发展具有一定抑制作用，对预后有潜在益处；彩色多普勒超声能较好地监测急性胰腺炎的发生、进展及预后，对急性胰腺炎的治疗具有一定的指导作用。

Study on Effect of Statins in Treatment of Severe Acute Pancreatitis

Objective To investigate the clinical effect of statins in the treatment of severe acute pancreatitis by color Doppler ultra-sound. Methods 97 cases of severe acute pancreatitis from June 2012 to May 2013 were collected and divided into the control group and the experimental group. The control group were given the routine treatment of pancreas resting therapy, fluid resuscitation, anti-in-fection, nutrition support, operation, etc. The experimental group was added with statins. The clinical effects were compared between the two groups. The pancreatic image situation was observed by the color Doppler ultrasound and analyzed. Resuts The ultrasound on 1 d after admission showed that the pancreatic parenchyma echo in the two groups was reduced and uneven with vague envelope, the occur-rence rate of peripancreatic and peritoneal effusion had no difference between the two groups;the ultrasonic pancreatic parenchyma echo after 7, 14 d treatment in the experiment group was changed, the occurrence rate of fuzzy envelope was significantly less than that in the control group （ P〈0. 05 ） , the thickness of pancreatic head, pancreatic body and pancreatic duct expansion degree on 1 d after admis-sion had no statistically significant differences between the two groups （ P〉0. 05 ） , the thickness of pancreatic head, pancreatic body and pancreatic duct expansion degree after 7, 14 d treatment in the experimental group were significantly less than those in the control group （ P〈0. 05 ） , the pancreatic body thickness after 14 d treatment in the treatment group was obviously less than that in the control group （ P〈0. 05 ） . Conclusion Statins has certain inhibiting effect on the inflammation progress of severe acute pancreatitis and the potential benefit on prognosis;the color Doppler ultrasound can better monitor the development, progress and prognosis of severe acute pancreatitis and has certain guidance role for the treatment of acute pancreatitis.