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注射用头孢唑林钠与丹皮酚磺酸钠注射液配伍稳定性研究
引用本文:陈锡创,;洪远,;冯锦华,;糜菁熠,;尤晓红. 注射用头孢唑林钠与丹皮酚磺酸钠注射液配伍稳定性研究[J]. 中国药业, 2014, 0(17): 10-12
作者姓名:陈锡创,  洪远,  冯锦华,  糜菁熠,  尤晓红
作者单位:[1]江苏省无锡市第九人民医院·无锡市手外科医院,江苏无锡214062; [2]南京医科大学附属无锡市儿童医院,江苏无锡214023
基金项目:江苏省常州四药临床药学科研基金,项目编号:CSZOON1140.
摘    要:目的:观察注射用头孢唑林钠与丹皮酚磺酸钠注射液在0.9%氯化钠注射液中的配伍稳定性。方法模拟临床使用条件,用高效液相色谱法测定头孢唑林钠与丹皮酚磺酸钠配伍后6 h内的相对百分含量,并观察其外观、不溶性微粒数及pH变化。结果头孢唑林钠与丹皮酚磺酸钠配伍后,在室温下放置6 h,配伍液的外观、不溶性微粒数、pH及含量均无明显变化。结论注射用头孢唑林钠与丹皮酚磺酸钠注射液在0.9%氯化钠注射液中配伍后,室温下6 h内可使用。

关 键 词:头孢唑林钠  丹皮酚磺酸钠  配伍稳定性  高效液相色谱法

Study on Compatible Stability of Cefazolin Sodium Injection with Sodium Paeonol Sulfonate Injection
Affiliation:Chen Xichuang, Hong Yuan, Feng Jinhua, Mi Jingyi, You Xiaohong (1. Wuxi Municipal Ninth People's Hospital, Wuxi Municipal Hand Surgery Hospital, Wuxi, Jiangsu, China 214062; 2. Affiliated Wuxi Children's Hospital, Nanjing Medical University, Wuxi, Jiangsu, China 214023)
Abstract:Objective To study the compatible stability of Cefazolin Sodium Injection with Sodium Paeonol Sulfonate Injection in 0.9% Sodium Chloride Injection. Methods The high performance liquid chromatography (HPLC) was adopted to detect the relative percentage content of cefazolin sodium and sodium paeonol sulfonate within 6 h in stimulated clinical conditions. The appearance of the solution, pH value and the number of insoluble particles were observed. Results There were no evident changes in the appearance, pH value, number of insoluble particles and the content of cefazolin sodium and sodium paeonol sulfonate of the compatible solution within 6 h at room temperature. Conclusion The compatible solution of Cefazolin Sodium Injection with Sodium Paeonol Sulfonate Injection in 0. 9% Sodium Chloride Injection can be used within 6 h at room temperature .
Keywords:cefazolin sodium reaction  sodium paeonol sulfonate  compatible stability  HPLC
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