| 桂枝茯苓胶囊主要效应成分在比格犬体内的药代动力学 |
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| 引用本文： | 朱克近,孙晓萍,常秀娟,秦建平,吕新勇,王振中,萧伟.桂枝茯苓胶囊主要效应成分在比格犬体内的药代动力学[J].中国中药杂志,2011,36(8):1015-1018. |
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| 作者姓名： | 朱克近 孙晓萍 常秀娟 秦建平 吕新勇 王振中 萧伟 |
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| 作者单位： | 江苏康缘药业股份有限公司,江苏,连云港,222001;中药制药过程新技术国家重点实验室,江苏,连云港,222001;江苏省企业院士工作室,江苏,连云港,222001 |
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| 基金项目： | 国家重大新药创制专项(2009ZX09504-004) |
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| 摘 要： | 目的:研究桂枝茯苓胶囊中主要成分芍药苷、芍药内酯苷、苦杏仁苷在比格犬体内的药代动力学特征.方法:比格犬口服给予桂枝茯苓胶囊0.044 8,0.179 2 g·kg-1后,前肢静脉收集血浆样本,经固相萃取小柱富集后,HPLC-MS/MS检测血药浓度,DAS 2.0软件计算药代动力学参数.结果:芍药苷、芍药内酯苷、苦杏仁苷体内检测定量限分别为0.25,2.64,0.04μg·L-1,不同剂量下芍药苷t1/2分别为4.33,3.62 h;芍药内酯苷t1/2分别为6.16,5.91 h,苦杏仁苷t1/2分别为2.43,1.32 h;各成分体内AUC0-t与剂量有较好相关性.结论:芍药苷、芍药内酯苷、苦杏仁苷在体内均有较高暴露量,可用二室模型来描述.
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| 关 键 词： | 芍药苷 芍药内酯苷 苦杏仁苷 桂枝茯苓胶囊 药代动力学 |
| 收稿时间： | 2011/3/16 0:00:00 |
Pharmacokinetics of Guizhi Fuling capsule in beagle dogs |
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| ZHU Kejin,SUN Xiaoping,CHANG Xiujuan,QIN Jianping,LV Xinyong,WANG Zhenzhong and XIAO Wei.Pharmacokinetics of Guizhi Fuling capsule in beagle dogs[J].China Journal of Chinese Materia Medica,2011,36(8):1015-1018. |
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| Authors: | ZHU Kejin SUN Xiaoping CHANG Xiujuan QIN Jianping LV Xinyong WANG Zhenzhong and XIAO Wei |
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| Institution: | Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China |
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| Abstract: | Objective: To investigate pharmacokinetic parameters of peoniflorin,albiflorin and amygdaloside after administration of Guizhi Fuling capsule in beagle dogs.Method: Plasma was collected from forelimb vein of Beagle dogs after oral administration of GuizhiFuling capsule.HPLC-MS/MS method was used to determine the concentrations of constituents in plasma.The pharmacokinetic parameters were analyzed by program DAS 2.0.Result: The limit of quantitation of peoniflorin,albiflorin and amygdaloside were 0.25,2.64,0... |
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| Keywords: | peoniflorin albiflorin amygdaloside Guizhi Fuling capsule phamacokinetics |
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