2型糖尿病肾阴虚证家族聚集性分析

目的分析2型糖尿病(type 2 diabetic mellitus，T2DM)肾阴虚证的家族聚集性和遗传倾向。方法收集南京地区T2DM阴虚证患者(先证者)32例，32个家系共141例，运用家系分析的方法对肾阴虚的患病特征进行遗传分析，包括计算先证者一级亲属患病率、遗传度；并运用多因素回归分析的方法评估肾阴虚家族史在肾阴虚发生中的作用。结果T2DM肾阴虚先证者一级亲属肾阴虚患病率为33．71％，运用Falconer公式计算肾阴虚证的遗传度为80．6％。多因素Logistic回归拟合结果显示肾阴虚家族史在肾阴虚的发病中占有重要地位(OR=5．61，P=0．001)，而T2DM本身并非肾阴虚的独立发病危险因素。结论T2DM肾阴虚证具有家族聚集倾向和遗传倾向，遗传因素与肾阴虚的发生有一定的关系；家系研究的方法是开展中医证侯与遗传因素关系研究较好的工具。

Familial Pedigree Analysis of Shen-Yin Deficiency Syndrome in Families with Type 2 Diabetes Mellitus

ObjectiveTo analyse the familial aggregation and genetic predisposition of Shen-yin deficiency syndrome (SYDS) in families with diabetes mellitus type 2 (DM2). MethodsOne hundred and forty-one DM2 patients were collected from 32 family lines in Nanjin area, in which the probands were differentiated as DM2 with SYDS. On them, genetic analysis on the characteristics of SYDS was conducted using pedigree analysis, morbidity and heritability of the first-degree relatives of the probands were calculated, and the action of familial SYDS factor on the genesis of the syndrome was assessed by multiple factors regression analysis. ResultsThe morbidity rate of SYDS in the first-degree relatives of the probands was 33.71%, and the heritability, calculated by Falconer formula, was 80.6%. The fitting result of regression analysis showed that familial factor played an important role in SYDS genesis (OR=5.61, P=0.001), but DM2 itself is not an independent risk factor for it. ConclusionDM2 with SYDS shows the tendency of familial aggregation and genetic predisposition, genetic factor is associated with the genesis of the syndrome. Pedigree research is a good method for exploring the relationship between syndrome and genetic factor.