| 中脑导水管周围灰质内催产素在电针镇痛中作用机制的研究 |
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| 引用本文： | 刘文彦,张艳霞,刘玉红,葛凤,冀强,白波.中脑导水管周围灰质内催产素在电针镇痛中作用机制的研究[J].济宁医学院学报,2002,25(3):8-10. |
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| 作者姓名： | 刘文彦 张艳霞 刘玉红 葛凤 冀强 白波 |
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| 作者单位： | 济宁医学院生理学教研室 |
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| 基金项目： | 山东省自然科学基金资助课题 (No.Q98C0 112 4) |
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| 摘 要： | 目的：探讨中脑导水管周围灰质（PAG）内催产素（OT）与内源性强啡肽在电针镇痛中的关系。方法：以钾离子透入法引起大鼠甩尾反应的电流强度（mA）为痛行为反应的指标，观察向PAG内注入OT和抗强啡肽A1-13血清，对动物电针镇痛效应的影响。结果：PAG内注入OT后，大鼠电针镇痛的效应明显升高；而注入抗强啡肽血清后，对OT电针镇痛的效应无显著影响。结论：PAG内OT在电针镇痛中发挥着重要的作用，且其作用不依赖于PAG内的内源性强啡肽。
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| 关 键 词： | 催产素 抗强啡肽血清 导水管周围灰质 电针镇痛 |
THE EFFECT OF OXYTOCIN IN PERIAQUEDUCTAI GRAY ON ELECTROACUPUNCTURE ANALGESIA OF RATS |
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| Liu Wenyan,Zhang Yanxia,Liu Yuhong,et al.THE EFFECT OF OXYTOCIN IN PERIAQUEDUCTAI GRAY ON ELECTROACUPUNCTURE ANALGESIA OF RATS[J].Jounal of Jinning Medical College,2002,25(3):8-10. |
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| Authors: | Liu Wenyan Zhang Yanxia Liu Yuhong |
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| Abstract: | Objective To study the effect of oxytocin(OT) on electroacupuncture analgesia in periaqueductal gray(PAG) and its relation to endogenous dynorphin A 1-13 .Methods Potassium iontophoresis induced tail-flick was used to measure the pain threshold.Results OT administration induced an enhancement of electroacupuncture analgesia.Furthermore,pre-injection of ADYNS in PAG could not weaken analgesia effect of OT.Conclusion These data suggest the enhancement of electroacupuncture analgesia by OT is not dependent upon the dynorphin A 1-13 in PAG. |
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| Keywords: | Oxytocin Anti-dynorphin A 1-13 serum Periaqueductal gray Electroacupuncture analgesia |
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