Evidence of HTLV-I in thyroid tissue in an HTLV-I carrier with Hashimoto's thyroiditis |
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| Authors: | H. Kawai T. Mitsui K. Yokoi M. Akaike K. Hirose K. Hizawa S. Saito |
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| Affiliation: | (1) First Department of Internal Medicine, School of Medicine, The University of Tokushima, 3-8-15 Kuramoto, 770 Tokushima, Japan;(2) First Department of Pathology, School of Medicine,The University of Tokushima, 3-8-15 Kuramoto, 770 Tokushima, Japan |
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| Abstract: | Human T-lymphotropic virus type I (HTLV-I) protein and messenger RNA (mRNA) for HTLV-I were examined in thyroid tissues from two patients with Hashimoto's thyroiditis and serum anti-thyroid antibody. The virus envelope protein and signals for the mRNA were detected in many of the follicular epithelial cells of the thyroid tissue from one of the patients, respectively, by immunohistochemistry and in situ hybridization. PCR-Southern blotting revealed the presence of HTLV-I DNA in the thyroid tissue, in which the viral protein and mRNA were detected, although no virus particles were found in the epithelial cells by electron microscopy. HTLV-I virus was not present in the thyroid tissue from the second patient. The present findings suggest that infection of thyroid tissue with HTLV-I is associated with the pathogenesis of Hashimoto's thyroiditis in some patients.Abbreviations HTLV-I Human T-lymphotropic virus type 1 |
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| Keywords: | Human T-lymphotropic virus type I Hashimoto's thyroiditis Envelope protein Messenger RNA In situ hybridization |
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