乙醇性认知功能障碍研究新进展

乙醇具有神经毒性作用,长期大量使用可导致维生素B1的缺乏,脑胶质细胞减少,同型半胱氨酸水平增高,酪蛋白激酶活性降低,从而引起乙醇性认知功能障碍。其特点为大脑皮质功能受损,脑结构发生改变,记忆和流体认知功能障碍,一般智力、熟识的知识功能受损轻微。目前对乙醇性认知功能障碍的发病机制还不完全明确,部分机制研究还处于动物实验阶段,缺乏大样本的临床实验,有待得到进一步的发展。

The Progress of Alcohol Related Cognitive Dysfunction

Alcohol,which has neurotoxic effect,could lead to lack of vitamin B1 and cerebullar gliocyte,increasing of homocysteine and reduction of casein kinase 2,thereby could induce alcohol related cognitive dysfunction.The character of cognitive dysfunction includes cerebral cortex dysfunction,changes in brain structure,memory and fluid cognitive dysfunction,a little impairment of general intelligence and familiar knowledge.At present,the pathogenesis of alcohol related cognitive dysfunction is not completely clear,part of the mechanism researches are still in the stage of animal experiment,which lack a large sample of clinical trials pending further development in the future.