| 大鼠SmI施加密胆碱后电针与乙酰胆碱对束旁核伤害性反应的影响 |
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| 引用本文： | 吴国冀 陈正秋. 大鼠SmI施加密胆碱后电针与乙酰胆碱对束旁核伤害性反应的影响[J]. 针刺研究, 1995, 20(4): 30-33 |
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| 作者姓名： | 吴国冀 陈正秋 |
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| 作者单位： | 中国中医研究院针灸所!北京100700 |
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| 摘 要： | 本实验用玻璃微电极细胞外记录和微电泳的方法，观察到：电针“足三里”、“环跳”穴能够抑制丘脑束旁核（Pf）神经元的伤害性反应；用密胆碱（HC－3）处理大鼠皮层SmI后，电针的抑制作用被取消；微电泳外源性导入乙酰胆碱（ACh）后，丘脑Pf神经元的伤害性反应被抑制，此作用与HC－3处理SmI前的电针效应相似。由此提示：电针可通过激活大鼠皮层SmI释放ACh，抑制丘脑Pf神经元的伤害性反应。
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| 关 键 词： | 皮层SmI 丘脑束旁核 乙酰胆碱 密胆碱 伤害性反应 下行性调节 |
Influence of EA and ACh on Nociceptive Responses of Pf Neurons Following Topical Application of HC-3 at SmI in Rats |
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| Abstract: | The influences of EA and iontophoretic ACh on nociceptive responses of Pf neurons following topical application of HC-3 at Sml were recorded extracellularly by multi-microelectrodes in rats. It was found that EA could inhibit the nociceptive responses of Pf neurons; the inhibition could be eliminated by topical application of HC-3 at SmI; iontophoretic ACh could also induce the inhibition, which was similar to the effect of EA obtained before HC-3 application at SmI. The results indicate that EA can inhibit the nociceptive responses of Pf neurons through SmI releasing ACh. |
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