血管紧张素Ⅱ在脊髓水平可增强电针的抑制效应

本实验观察了血管紧张素Ⅱ（AII）对脊髓腰段（L2～3）背角神经元伤害性诱发放电的影响，AⅡ（50～500ng）对伤害性诱发放电主要为抑制效应，而较大剂量（2ug）则呈相反效应；AⅡ（250ng）能增强电计“足三里”及“三阴交”穴的抑制效应。实验结果提示AⅡ参与脊髓水平的痛觉信息调制作用。

Angiotensin Ⅱ Increasing the Inhibitory Effects of Electroacupuncture on the Nociceptive Discharge of Neurons in the Spinal Dorsal Horn

Experiments were performed on 53 rats. The nociceptive discharges of spinal dorsal horn neurons were extracellularly recorded by glass microelectrodes and tested for the effects of angiotensin Ⅱ(A Ⅱ ) on the nociceptive discharges of spinal dorsal horn neurons and AII on the inhibitory effects of electroacupuncture (EA ). The results showed as follows: (a) The nociceptive discharges of spinal dorsal horn neurons might be inhibited (25/35) or facilitated (10) with AⅡ (50～ 500ng/20ul) applied to the surface of dorsal spinal cord (L2-3 ); (b)The facilitory effects (5/5 ) were observed with A E (2ug/20ul)applied to the surface of dorsal spinal cord; (c) The inhibitory effects of EA (20Hz, 2 - 4V, 5min) could be increased with A Ⅱ (250mg/20ul, 8/9 ). Therefore, A Ⅱ may modulate the nociceptive response of spinal dorsal horn neurnons and influence the effects of EA, and different effects can be produced when the different dosage of A Ⅱ is applied to the surface of dorsal horn