联苯苄唑液局部治疗真菌性外耳道炎的临床研究

目的探讨联苯苄唑液局部治疗真菌性外耳道炎的可行性,为临床治疗提供参考。方法选择2010年9月至2011年9月于该院诊治的真菌性外耳道炎患者40例,随机分成对照组和研究组,其中对照组20例单纯行常规外耳道冲洗,研究组20例联合联苯苄唑液冲洗治疗。随访1～2个月,对比两组患者的临床疗效、病情积分及不良反应发生情况。结果所有患者的病情积分均低于治疗前,差异有统计学意义（P〈0.05）;两组间相比,研究组患者的病情积分优于对照组,差异有统计学意义（P〈0.05）;研究组患者治疗总有效率为95.0%,高于对照组的80.0%,差异有统计学意义（P〈0.05）;研究组不良反应仅发生2例（10%）,即轻度头晕1例、耳痒1例,研究组各种不良反应发生率均低于对照组（P〈0.05）。结论采用联苯苄唑液局部联合治疗真菌性外耳道炎,可有效改善患者病情,临床疗效显著,且安全性高,值得推广使用。

Clinical study on fungal inflammation of auditory canal treatment by bifonazole solution

Objective To observe the feasibility of local treatment of bifonazole solution on fungal inflammation of auditory canal,to provide the reference for the clinical treatment.Methods From September 2010 to September 2011,40 cases with patients fungal inflammation of auditory canal were divided into control group and research group,20 patients in each.Control group received conventional external auditory canal flushing,and research group received flushing treatment combined with bifonazole solution.All the patients were followed up for 1~2 months.Clinical efficacy,integration of illness and adverse drug reactions of the two groups were compared.Results After treatment,the integration of illness for all patients were lower than before treatment（P0.05）.The integration of illness in research group was better than control group（P0.05）.The total effective rate of the research group was 95.0%,which was higher than 80.0% of control group（P0.05）.And there was only two cases with adverse drug reactions in the research group（10%）,including 1 case with mild dizziness and another case with ear itching.The adverse drug reactions rate of research group was lower than that of the control group（P0.05）.Conclusion Applying local treatment of bifonazole solution on fungal inflammation of auditory canal might effectively improve clinical efficacy,which could be worthy of clinical and applicaton.