Electrolitholysis--from basic research to the formulation of a new therapeutic method

OBJECTIVE: An electrochemical method, based on anodic oxidation and/or protolysis, has been developed with the aim of extending it to the dissolution of urinary stones. The method has been named electrolitholysis, or ELLYS. An ex vivo experimental trial has been performed to check the current intensity needed to obtain the dissolution of stones without lesions to tissues. A new therapeutic method has been conceived based on these preliminary findings. MATERIALS AND METHODS: An ex vivo experimental trial has been performed on twelve bladders surgically removed from pigs and placed in an experimental model resembling possible vital organs; the electrolytic dissolution of natural urinary stones was then performed in these bladders. RESULTS: The ex vivo trial showed that the method is safe and reliable if the current intensity is maintained at < or =30 mA. CONCLUSIONS: A new therapy based on a new concept has been conceived which can be delivered percutaneously through an electrified spiral stent implanted several days into renal cavities and connected with a power supplier (battery) attached to the patient's flank.