| 脑室注射BDNF对抑郁症大鼠海马神经元前体细胞微管相关蛋白Doublecortin表达的影响 |
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| 引用本文： | 田竞,杨忠,吴喜贵,殷烈虎,李学成,陆地,蒋渝,吴红辰.脑室注射BDNF对抑郁症大鼠海马神经元前体细胞微管相关蛋白Doublecortin表达的影响[J].免疫学杂志,2009,25(3). |
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| 作者姓名： | 田竞 杨忠 吴喜贵 殷烈虎 李学成 陆地 蒋渝 吴红辰 |
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| 作者单位： | 田竞,杨忠,吴喜贵,TIAN Jing,YANG Zhong,WU Xigui(第三军医大学基础部神经生物教研室);殷烈虎,李学成,陆地,蒋渝,吴红辰,YING Liehu,LI Xuecheng,LU Di,JIANG Yu,WU Hongchen(解放军第324医院精神病科)
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| 摘 要： | 目的 探讨脑源性神经营养因子(brain-drived neurotrophic factor,BDNF)对抑郁症大鼠海马神经元前体细胞微管相关蛋白Doublecortin(DCX)表达的影响,为BDNF如何影响神经元前体细胞的增殖、迁移提供实验依据.方法 成功建立抑郁症大鼠模型后,向脑室注射0.5 μg BDNF,取脑组织行冰冻切片.采用免疫组织化学和免疫荧光技术观察DCX阳性细胞表达情况及表达部位.结果 相对于未注射BDNF的抑郁症大鼠,注射组大鼠海马区域DCX阳性细胞数明显增多,且与未注射组存在明显差异(P＜0.05).结论 BDNF可能通过调控抑郁症大鼠海马神经元前体细胞微管相关蛋白DCX的表达,从而影响抑郁症时神经元前体细胞的分化和迁移.
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| 关 键 词： | 脑源性神经营养因子 抑郁症 大鼠 海马 微管相关蛋白 |
Effects of intracerebroventricular injection of BDNF on the expression of neuronal precursors microtubule-associated protein doublecortin in hippocampus of depressed rats |
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| TIAN Jing,YANG Zhong,WU Xigui,YING Liehu,LI Xuecheng,LU Di,JIANG Yu,WU Hongchen Depactment of Neunbiology,Third Military Medical University,Chongqing ,China.Effects of intracerebroventricular injection of BDNF on the expression of neuronal precursors microtubule-associated protein doublecortin in hippocampus of depressed rats[J].Immunological Journal,2009,25(3). |
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| Authors: | TIAN Jing YANG Zhong WU Xigui YING Liehu LI Xuecheng LU Di JIANG Yu WU Hongchen Depactment of Neunbiology Third Military Medical University Chongqing China |
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| Institution: | TIAN Jing,YANG Zhong,WU Xigui,YING Liehu,LI Xuecheng,LU Di,JIANG Yu,WU Hongchen Depactment of Neunbiology,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Objective To investigate the effects of brain-drived neurotrophic factor (BDNF) on the expression of neuronal precursors microtubule-associated protein doublecortin in hippocampus of depressed rats and provide experimental evidence for the effects of BDNF on the proliferation and migration of neuronal precursors. Methods Depressed rat model was established,and 0.5 ug of purified BDNF was injected into rat cerebral ventricle for preparing frozen section. Immunohistochemistry and immunofluorescence were emplo... |
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| Keywords: | brain-drived neurotrophic factor depression rat hippocampus microtubule-associated protein |
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