| 紫菀水提取物体内抗肿瘤作用 |
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| 引用本文： | 贺志安,马兴科,白素平.紫菀水提取物体内抗肿瘤作用[J].新乡医学院学报,2006,23(4):332-334. |
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| 作者姓名： | 贺志安 马兴科 白素平 |
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| 作者单位： | 1. 新乡医学院医学检验系,河南,新乡,453003
2. 周口师范学院化学系,河南,周口,466000 |
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| 基金项目： | 河南省科技厅科技攻关项目 |
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| 摘 要： | 目的研究紫菀水提取物的体内抗肿瘤作用。方法制作荷瘤S180小鼠和荷HePA小鼠模型,用3种浓度紫菀水提取物,进行小鼠体内抗肿瘤试验。结果紫菀水提取物2.50 g.kg-1.d-1和5.00g.kg-1.d-1组瘤重明显低于阴性对照组(P<0.05,P<0.01),抑瘤率分别是18.94%、57.71%,有量效依存关系;提取物对荷HepA肿瘤小鼠抑制作用不明显(P>0.05)。结论紫菀水提取物的抗肿瘤活性有选择性,对荷S180小鼠肿瘤增殖有较好的抑制的作用。
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| 关 键 词： | 紫菀 水提取物 抗肿瘤作用 |
| 文章编号： | 1004-7239（2006）04-0332-03 |
| 收稿时间： | 2006-05-02 |
| 修稿时间： | 2006-05-02 |
Anti-tumor effect of the Aster water extract in vivo |
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| HE Zhi-an,MA Xing-ke,BAI Su-ping.Anti-tumor effect of the Aster water extract in vivo[J].Journal of Xinxiang Medical College,2006,23(4):332-334. |
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| Authors: | HE Zhi-an MA Xing-ke BAI Su-ping |
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| Abstract: | Objective To discover anti-tumor function of Aster water extract in vivo.Methods Dutch S_(180) and HepA mouse models were established,and anti-tumor effects in mouse in vivo was performed with three kinds of concentration of Aster water extract.Results The Aster water extract with 2.50 g·kg~(-1)·d~(-1) and 5.00 g·kg~(-1)·d~(-1) were remarkable inhibition of development of tumor in the Dutch S_(180) mouse,compared with the negative group(P<0.05 and P<0.01), respectively.And the inhibitory tumor rate was 18.94% and 57.71% which was demonstrated the dose-effect relationship.Unobvious inhibitory function of Aster water extract was for Dutch HepA tumor mouse(P>0.05).Conclusion Antineoplasmic activity of Aster water extract shows selectivity,and Aster water extract exists a better inhibitive effect on development of the Dutch S_(180) mouse's tumor. |
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| Keywords: | Aster tataricus L f water extract anti-tumor function |
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