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九节龙皂苷Ⅰ的抗肿瘤作用和免疫调节作用
引用本文:陶小军,龙静雯,贺建宇,姚鸿萍,刘静,曹永孝.九节龙皂苷Ⅰ的抗肿瘤作用和免疫调节作用[J].中国药理学通报,2005,21(9):1070-1073.
作者姓名:陶小军  龙静雯  贺建宇  姚鸿萍  刘静  曹永孝
作者单位:1. 西安交通大学,医学院药理学系,陕西,西安,710061
2. 西安交通大学,医学院药理学系,陕西,西安,710061;西安交通大学,环境与疾病相关基因教育部重点实验室,陕西,西安,710061
摘    要:目的研究九节龙皂苷Ⅰ对S180、H22、EAC和L1210荷瘤小鼠的治疗作用及对荷瘤小鼠免疫功能的影响。方法小鼠右腋皮下(或腹腔)接种瘤细胞复制荷瘤小鼠模型。连续灌胃给药九节龙皂苷Ⅰ8 d后,剥离瘤块,计算抑瘤率;3H-TdR参入法研究了其对脾淋巴细胞增殖的影响,腹腔巨噬细胞吞噬鸡红细胞法测量了其对巨噬细胞吞噬功能的影响。结果九节龙皂苷Ⅰ对小鼠S180、H22和EAC实体瘤均有抑制作用,其100 mg.kg-1对3种移植瘤最大抑瘤率分别为38.7%、48.6%和50.0%;并能促进荷瘤小鼠脾T淋巴细胞增殖,提高巨噬细胞吞噬能力。结论九节龙皂苷Ⅰ能抑制小鼠移植性肿瘤生长,并能改善荷瘤小鼠免疫功能。

关 键 词:九节龙皂苷Ⅰ  抗肿瘤  免疫调节
文章编号:1001-1978(2005)09-1070-04
收稿时间:2005-01-08
修稿时间:2005-04-04

Antitumor and immunological regulation effects of ardipusilloside-Ⅰ
TAO Xiao-jun,LONG Jing-wen,He Jian-yu,YAO Hong-ping,LIU Jing,CAO Yong-xiao.Antitumor and immunological regulation effects of ardipusilloside-Ⅰ[J].Chinese Pharmacological Bulletin,2005,21(9):1070-1073.
Authors:TAO Xiao-jun  LONG Jing-wen  He Jian-yu  YAO Hong-ping  LIU Jing  CAO Yong-xiao
Abstract:Aim To study the antitumor and immunological regulation effects of ardipusilloside-Ⅰ(ADS-Ⅰ) on tumor-bearing mice of S180, H22, EAC and L1210. Methods The tumor-bearing mouse model was made through injecting cancer cells in the right limb oxter(or in abdominal cavity), and the mice were administrated orally with ADS-Ⅰfor 8 days. Then we detached the tumor and counted the inhibition rate of tumor growth. Incorporation of ()~3H-TdR was used to assess the proliferation of T spleen lymphocyte cells; phagocytosis of abdominal cavity macrophage was measured with the method of chicken red blood cells. Results ADS-Ⅰ was proved to be effective on the tumor-bearing mice of S180, H22 and EAC, and the maximal inhibition rate of the dose of 100 mg·kg~(-1) was 38.7%, 48.6% and 50.0%, respectively;ADS-Ⅰ promoted the proliferation of T spleen lymphocyte cells,and strengthened the phagocytosis of macrophage in the tumor-bearing mice significantly. Conclusion ADS-Ⅰ can inhibit the growth of transplanted tumor,and improve the immunological function of tumor-bearing mice.
Keywords:ardipusilloside-Ⅰ(ADS-Ⅰ)  antitumor  immunological regulation
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