乳腺癌超声造影边缘增强特征及定量参数与免疫指标的相关性分析

摘要] 目的 研究乳腺癌超声造影边缘带增强特征及定量参数与免疫组化指标的相关性。方法 收集2016年9月至2019年7月山西医科大学第一医院行超声造影检查的乳腺癌女性患者76例（76个病灶），所有患者经术后病理及免疫组化证实，且术前均未进行放化疗治疗，观察超声造影后乳腺癌病灶边缘增强特征及定量参数，分析其与ER、PR、HER-2、Ki-67的相关性。结果 乳腺癌病灶边缘放射状增强与ER、Ki67阳性表达相关；穿支增强与HER-2阳性表达相关；造影后范围扩大与ER、HER-2、Ki67阳性表达相关；边缘增强特征与Ki67阳性表达相关；差异均有统计学意义（P<0.05）。乳腺癌边缘带定量参数PI、AUC以及Grad与Ki-67阳性表达呈正相关，TTP与ER、PR阳性表达呈负相关，差异均有统计学意义（P<0.05）。结论 乳腺癌超声造影边缘增强特征及定量参数与ER、PR、HER-2、Ki-67具有一定的相关性，可以对乳腺癌患者术前精准治疗方式的选择提供一定的参考依据。

Correlation analysis of marginal zone enhancement features and quantitative parameters of contrast-enhanced ultrasound with immunochemical indexes in the breast cancer

Abstract] Objective To explore the correlation between marginal zone enhancement features and quantitative parameters of contrast-enhanced ultrasound and immunochemical indexes in the breast cancer. Methods 76 patients were collected from the Department of Ultrasound, the First Affiliated Hospital of Shanxi Medical University from January 2016 to July 2019. A total of 76 breast cancer lesions were confirmed by biopsy or surgical pathology, and no radiotherapy or chemotherapy before angiography. The edge enhancement characteristics and quantitative parameters of breast cancer were analyzed, and their correlations with ER, PR, HER-2 and Ki-67 were analyzed. Results The correlation between marginal enhancement features and immunohistochemical factors in breast cancers were analyzed, we found that Radial enhancement was correlated with ER and Ki67 expression. Perforator enhancement was correlated with Her-2 expression. The range enlargement after angiography was correlated with the expressions of ER, Her-2 and Ki67, edge enhancement was correlated with Ki67 expression. and the differences were statistically significant (P<0.05). The PI, AUC and Grad were positively correlated with the positive expression of Ki-67.The TTP were negatively correlated with the positive expression of ER and PR,and the differences were statistically significant (P<0.05). Conclusion The marginal zone contrast enhancement features and quantitative parameters of breast cancer have certain correlation with ER, PR, HER-2 and Ki-67, which can provide a reference for the selection of preoperative precise treatment methods for breast cancer patients.