| 降低AFP诊断阈值并联合检测DCP显著提高肝细胞癌的诊断率 |
| |
| 引用本文： | 周宇辰,袁国盛,胡承光,刘俊维,任彦瑜,唐淬蓉,于乐成,杨定华. 降低AFP诊断阈值并联合检测DCP显著提高肝细胞癌的诊断率[J]. 肝脏, 2019, 24(5): 507-509,518 |
| |
| 作者姓名： | 周宇辰 袁国盛 胡承光 刘俊维 任彦瑜 唐淬蓉 于乐成 杨定华 |
| |
| 作者单位： | 510515广州 南方医科大学南方医院肝胆外科;南方医科大学中西医结合医院外科;510515广州,南方医科大学南方医院感染内科;东部战区总医院,南京中医药大学附属八一医院,全军肝病中心;510515广州,南方医科大学南方医院肝胆外科 |
| |
| 基金项目： | 国家自然科学基金;国家自然科学基金 |
| |
| 摘 要： | 目的评价甲胎蛋白(AFP)和脱-γ-羧基凝血酶原(DCP)联合检测对肝细胞癌(HCC)的诊断效能。方法选取临床诊断为HCC的患者75例和非HCC患者53例为研究对象,同时检测血清AFP和DCP浓度,分别绘制AFP、DCP和二者联合检测时的ROC曲线,计算最佳诊断阈值并评价其诊断效能。结果AFP及DCP诊断HCC的ROC曲线下面积分别为0.789和0.882;当AFP诊断阈值降为22.6ng/mL时,诊断效能最佳(灵敏度为66.7%、特异性为88.7%);DCP诊断HCC的最适阈值为39.0mAU/mL,灵敏度为72.0%、特异性为94.3%;二者联合检测诊断HCC的灵敏度为77.3%、特异性为90.6%。结论DCP对于HCC的鉴别诊断具有重要价值,降低AFP诊断阈值并联合DCP检测可显著提高对HCC的诊断率。
|
| 关 键 词： | 肝细胞癌 甲胎蛋白 脱-Γ-羧基凝血酶原 灵敏度 特异性 |
The diagnostic value of combined determining of serum AFP and DCP on early detection of HCC |
| |
| ZHOU Yu-chen,YUAN Guo-sheng,HU Cheng-guang,LIU Jun-wei,REN Yan-yu,TANG Cui-rong,YU Yue-cheng,YANG Ding-hua. The diagnostic value of combined determining of serum AFP and DCP on early detection of HCC[J]. Chinese Hepatology, 2019, 24(5): 507-509,518 |
| |
| Authors: | ZHOU Yu-chen YUAN Guo-sheng HU Cheng-guang LIU Jun-wei REN Yan-yu TANG Cui-rong YU Yue-cheng YANG Ding-hua |
| |
| Affiliation: | (Department of Hepatobiliary Surgery,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China;Department of Infectious Diseases and Hepatology Unit,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China;Department of Surgery,TCM-Integrated Hospital,Southern Medical University,Guangzhou,510315,China;Liver Diseases Center,General Hospital of Eastern Theater Command,and Bayi Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210002,China) |
| |
| Abstract: | ZHOU Yu-chen;YUAN Guo-sheng;HU Cheng-guang;LIU Jun-wei;REN Yan-yu;TANG Cui-rong;YU Yue-cheng;YANG Ding-hua(Department of Hepatobiliary Surgery,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China;Department of Infectious Diseases and Hepatology Unit,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China;Department of Surgery,TCM-Integrated Hospital,Southern Medical University,Guangzhou,510315,China;Liver Diseases Center,General Hospital of Eastern Theater Command,and Bayi Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210002,China) |
| |
| Keywords: | Hepatocellular carcinoma Alpha-fetoprotein Des-gamma-carboxyprothrombin Sensitivity Specificity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
