脑出血后继发性脑损伤的机制与治疗

脑出血具有高发病率和高死亡率的特点。近年研究表明,脑出血产生的继发性脑损伤机制主要涉及凝血酶诱导、红细胞裂解、毒性反应、氧化损伤和炎症反应等多个方面。根据不同的损伤机制,应运而生了多种脑出血的治疗策略,但是否能成功应用于临床还有待进一步研究。本文对脑出血后继发性损伤的潜在机制和新兴治疗方法进行了综述。

Mechanism and Treatment of Secondary Brain Injury after Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) has high mortality and morbidity. Recent studies
have shown that the mechanism of secondary brain injury caused by ICH mainly involves the
thrombin-induced injury, red blood cell lysis, toxic reaction, oxidative injury, inflammation and so
on. According to different injury mechanism, several emerging therapeutic strategies for cerebral
hemorrhage have developed. However, there are few therapies that can be successfully applied in
clinic, which need to be further studied. This article mainly reviewed the potential mechanism and
the emerging treatment methods of secondary brain injury after ICH.