正念干预对炎症性肠病患者抑郁、焦虑及生活质量影响的Meta分析

目的评价正念干预对炎症性肠病(IBD)患者抑郁、焦虑及生活质量的影响,为IBD患者正念干预的临床应用提供循证参考。方法对PubMed、Embase、PsycINFO、Cochrane Library、中国知网、万方数据库、中国生物医学文献数据库进行检索,收集关于正念疗法干预IBD患者的随机对照研究的相关数据,采用RevMan 5.3进行Meta分析。结果共纳入5项随机对照研究,包括319例IBD患者,其中干预组163例,对照组156例。Meta分析结果显示,干预结束时,与对照组相比,正念干预组抑郁水平更低,差异有统计学意义(SMD=-0.56,95%CI:-0.87^-0.26,P<0.05),正念干预对IBD患者焦虑水平(SMD=-0.15,95%CI:-0.59~0.30,P=0.52)、生活质量(SMD=0.13,95%CI:-0.20~0.47,P=0.44)的改善无统计学意义;长期随访,与对照组相比,正念干预对IBD患者抑郁、焦虑及生活质量的改善差异无统计学意义(P>0.05)。结论正念干预可能有助于降低IBD患者抑郁水平,但长期效应尚不明确。

Effect of mindfulness-based intervention on depression, anxiety and quality of life among patients with inflammatory bowel disease: a Meta-analysis

Objective To investigate the effect of mindfulness-based intervention on depression, anxiety and quality of life among patients with inflammatory bowel disease(IBD), so as to provide evidence for clinical application of mindfulness-based intervention for IBD patients.Methods Randomized controlled trials (RCTs) related to mindfulness-based intervention for IBD published on English database (PubMed, Embase, PsycINFO, Cochrane Library) and Chinese database (CNKI, Wanfang and CBMdisc) were retrieved, and all statistical calculations were completed by RevMan 5.3 software.Results A total of 319 IBD patients in 5 RCTs were enrolled, including 163 case in intervention group and 156 cases in control group. Meta-analysis showed that the mindfulness-based intervention could alleviate the depression status of IBD patients (SMD=-0.56, 95% CI: -0.87~-0.26, P<0.05), while the improvement on anxiety status (SMD=-0.15, 95% CI: -0.59~0.30, P=0.52) and quality of life (SMD=0.13, 95% CI: -0.20~0.47, P=0.44) of intervention group showed no significant difference with those of control group. Follow-up revealed that the long-term effects of mindfulness-based intervention on depression, anxiety and quality of life in IBD patients were not significantly different from those of control group (P>0.05).Conclusion Mindfulness-based intervention can alleviate the depression level in patients with IBD, but its long-term effect remains obscure.