冠状动脉病变程度和血浆脑钠肽超敏C反应蛋白水平相关性的研究

目的 探讨冠心病患者冠状动脉病粥样硬化程度和血浆脑钠肽（BNP）、超敏C反应蛋白（hs-CRP）水平之间的相关性。方法163例经冠状动脉造影确诊为冠心病的患者分为稳定型心绞痛（SAP）组（79例）、不稳定型心绞痛（UAP）组（43例）和急性心肌梗死（AMI）组（41例），比较三组患者的冠状动脉病变支数、左主干病变、冠状动脉Gensini评分、血浆BNP和hs-CRP水平差异有无统计学意义。结果 三组患者的冠状动脉病变支数、左主干病变比较，差异有统计学意义（P〈0．01）；SAP组患者的Gensini评分、BNP、hs-CRP水平分别与UAP组和AMI组比较，差异有统计学意义（P〈0．01）；UAP组和AMI组患者的hs-CRP水平比较，差异有统计学意义（P〈0．05），两组患者的Gensini评分、BNP水平比较，差异无统计学意义（P〉0．05）。结论 冠心病患者的血浆BNP、hs-CRP水平和冠状动脉病变程度之间存在的相关性，可以反映心肌受损的程度，具有重要的临床意义。

Correlation of coronary artery stenosis with plasma levels of B-type natriuretic peptide and high-sensitive C-reactive protein

Objective To study the correlation of coronary artery stenosis with plasma levels of B-type natriuretic peptide(BNP)and high-sensitive C-reactive protein(hs-CRP)in the patients with coronary atherosclerotic heart disease.Method 163 patients with coronary heart disease diagnosed by coronary arteriography were divided into three groups:stable angina pectoris(SAP)group of 79 cases,unstable angina pectoris(UAP)group of 43 cases and acute myocardial infarction(AMI)group of 41 cases.Among the three groups,the number of impaired coronary arteries,left main coronary stenosis,Gensini scoring of coronary stenosis and plasma levels of BNP and hs-CRP were compared respectively.Result There were significant differences in the number of impaired coronary arteries and left main coronary stenosis among the three groups(P<0.01).Compared with the patients in UAP and AMI group,there were also significant differences in Gensini scoring,plasma levels of BNP and hs-CRP in the patients of SAP group(P<0.01).There was a significant difference in hs-CRP level(P<0.05),but there was no significant difference in BNP level and Gensini scoring(P>0.05)between the UAP and AMI group patients.Conclusion Plasma levels of BNP and hs-CRP correlates with coronary artery stenosis in patients with coronary heart disease.Both of them are important clinical parameters to reflect the severity of myocardial necrosis.