复杂性肾结石合并真菌感染的防治探讨

目的探讨复杂性肾结石真菌感染的常见原因和菌种分布,及微创经皮肾镜取石术(MPCNL)的治疗效果。方法对复杂性肾结石患者共计891例行中段尿培养,合并真菌感染者均行MPCNL治疗。结果891例复杂性肾结石中,真菌感染3.70%(33/891),其中白色念珠菌60.61%(20/33),光滑假丝菌39.39%(13/33),33例均有反复长期使用广谱抗菌素病史,使用时间25~92 d,中位数45.8 d,均为联合用药。33例真菌感染者均行MPCNL治疗,术后结石完全清除率87.88%(29/33),无意义结石残留率12.12%(4/33),术后肾功能有不同程度恢复,无1例出现大出血和真菌败血症。结论复杂性肾结石易并发真菌感染,应避免滥用广谱抗生素,MPCNL是治疗复杂性结石并发真菌感染安全、可靠的治疗方法。

The clinical analysis of patients with complex renal calculi combined with fungous infection

Objective To explore the etiology and the fungi distribution in patients with complex renal calculi,as well as the therapeutic efficacy of minimally invasive percutaneous nephrolithotomy(MPCNL).Methods The mid-stream urine culture was underwent in 891 cases of patients with complex renal calculi.The MPCNL were performed in patients with complex renal calculi combined with fungous infection.Results Of 891 patients with complex renal calculi,3.7%(33/891) patients were presented with fungous infection,including 60.61%(20/33) with Candida albicans and 39.39%(13/33) with Candida glabrata.All the 33 patients had long-term use of broad spectrum antibiotics from 25 to 92 days(averaged 45.8 days).The patients with complex renal calculi combined with fungous infection were treated with MPCNL.The stone-free rate was 87.88%(29/33) and the insignificance stone-residual rate was 12.12%(4/33).Conclusion The patients with complex renal calculi are apt to fungous infection and the abuse of broad spectrum antibiotics should be avoided.The MPCNL is safe and reliable for the treatment of the patients with complex renal calculi combined with fungous infection.