一氧化氮、内皮素与肝硬化及门静脉高压症病人肝功能的关系

目的　探讨一氧化氮（NO）,内皮素（ET-1）与肝硬化及门静脉高压症病人肝功能的关系。方法　按肝功能Ⅰ，Ⅱ，Ⅲ级分组比较肝炎后肝硬化、门脉高压病人血中的NO（酶法)、ET-1（放射免疫法)水平和肝功能的关系。结果　肝功能Ⅰ级组病人（13例）血中的NO水平远远低于肝功能Ⅱ级组（21例）和Ⅲ级组（21例）的病人［（22.7±2.3)μmol/L对(50.9±6.2)μmol/L和(51.9±5.7)μmol/L，P均<0.01)］，而血浆ET-1水平在肝功能Ⅰ，Ⅱ，Ⅲ级各组之间差异无显著意义［（49.6±8)pg/ml，(55.9±8.6)pg/ml和(54.2±11.2)pg/ml,P＞0.05）］。结论　血清NO在术前估价门静脉高压病人肝储备功能中有重要意义，而ET-1则未见明显价值。

Relationship between liver function and nitric oxide and endothelin-1 in patients with liver cirrhosis complicated with portal hypertension

Objective To investigate the relationship between changes in liver function and those in serum nitric oxide (NO) and endothelin 1 (ET 1) in patients with liver cirrhosis complicated with portal hypertension. Methods According to the liver function grading results, the patients were divided into groups A (grade I, n=13), B (grade II, n=21) and C (grade III, n=21). The levels of serum NO and ET 1 and index of liver function were determined. Then a comparison between the changes in liver function and those in serum NO and ET 1 was made by Nmenyi test. Results The serum level of NO was significantly lower in group A than in groups B and C (P<0 01). However, there was no significant difference in serum level of ET 1 among the 3 groups (P>0 05). Conclusions The serum NO, not ET 1, is of great significance in preoperative evaluation of the liver function of reservation in patients with liver cirrhosis complicated with portal hypertension.