| 6,8-二氟喹诺酮类抗菌药物的构效关系研究 |
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| 引用本文： | 傅旭春, 李光华. 6,8-二氟喹诺酮类抗菌药物的构效关系研究[J]. 中国现代应用药学, 1997, (1): 31-33. |
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| 作者姓名： | 傅旭春 李光华 |
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| 作者单位： | 浙江医科大学药学系!杭州，310031，浙江医科大学药学系!杭州，310031 |
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| 摘 要： | 研究了10个6,8-二氟喹诺酮类抗菌药在N1和C7位取代基的结构与抗菌活性的关系。结果表明,N1取代基除了必须符合适当的STERIMOL长度外,还要有一定的脂溶性;C7位取代基主要是脂溶性因素影响化合物的抗菌活性。
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| 关 键 词： | 6 8-二氟喹诺酮 抗菌药 构效关系 |
Study on the Structure-activity Relationships of 6, 8-difluoroquinolone Antibacterials |
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| Fu Xu-chun, Li Guang-hua. Study on the Structure-activity Relationships of 6, 8-difluoroquinolone Antibacterials[J]. Chinese Journal of Modern Applied Pharmacy, 1997, (1): 31-33. |
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| Authors: | Fu Xu-chun Li Guang-hua |
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| Abstract: | The structure-activity relationships of ten 6, 8-difluoroquinolones, have been studidd.The results showed that the N1-substitutent,should be lipophilic in addition to adapt theoptimal STERIMOL length. C7-substitutent affected the antibacterial activity of the olone because of its lipophilicity. |
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| Keywords: | 6 8-difluoroquinolone Antibacterials structure-activity relationships |
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