|
|||||
|
|
| 川芎嗪肉桂酰类双酯衍生物对内皮细胞氧化损伤的保护作用 | |
| 引用本文： | 丁倩,崔磊,矫春晓,王守训,刘新泳. 川芎嗪肉桂酰类双酯衍生物对内皮细胞氧化损伤的保护作用[J]. 潍坊医学院学报, 2009, 31(6): 426-428. DOI: 10.3969/j.issn.1004-3101.2009.06.009 |
| 作者姓名： | 丁倩 崔磊 矫春晓 王守训 刘新泳 |
| 作者单位： | 1. 潍坊医学院生物化学与分子生物学实验室,山东,潍坊,261053 2. 栖霞市人民医院心内科 3. 山东大学药学院 |
| 基金项目： | 山东省科技发展计划项目 |
| 摘 要： | 目的观察2，5-二（2，5-二甲氧基肉桂酰氧甲基）-3,6-二甲基吡嗪（TMPC）对H2O2引起的体外培养人脐静脉内皮细胞氧化性损伤的保护作用，并初步探讨其作用机制。方法 H2O2引起体外培养人脐静脉内皮细胞氧化性损伤，观察TMPC对内皮细胞氧化损伤的保护作用。结果TMPC对H2O2引起体外培养人脐静脉内皮细胞氧化性损伤有明显的保护作用，能减少内皮细胞脂质过氧化物丙二醛（Malondialdehyde，MDA）的生成，提高超氧化物歧化酶（SOD）活性，减轻H2O2诱导的内皮细胞内游离钙离子升高引起的钙超载。结论TMPC可有效保护H2O2引起体外培养人脐静脉内皮细胞氧化性损伤，维持或恢复细胞正常的生理功能，其机制可能与TMPC能有效抑制细胞内钙超载，减少脂质过氧化物的生成，提高抗氧化物质的活性有关。 |
| 关 键 词： | 川芎嗪衍生物 内皮细胞 氧化损伤 钙超载 |
Protective Effects of 2,5-bis(2,5-dimethoxy-cinnamoyoxymethyl)-3,6-Dimethyl Pyrazine on Endothelial Cells Injured by Hydrogen Peroxide |
|
| DING Qian,CUI Lei,JIAO Chun-xiao,WANG Shou-xun,LIU Xin-yong. Protective Effects of 2,5-bis(2,5-dimethoxy-cinnamoyoxymethyl)-3,6-Dimethyl Pyrazine on Endothelial Cells Injured by Hydrogen Peroxide[J]. Journal of Weifang Medical College, 2009, 31(6): 426-428. DOI: 10.3969/j.issn.1004-3101.2009.06.009 | |
| Authors: | DING Qian CUI Lei JIAO Chun-xiao WANG Shou-xun LIU Xin-yong |
| Affiliation: | DING Qian ,CUI Lei ,JIAO Chun-xiao ,WANG Shou-xun ,LIU Xin-yong (1Department of Biochemistry and Molecular Biology, Weifang Medical College, Weifang 261042; 2 Department of Cardiovascular, Qixia People Hospital ; 3 School of Pharmaceutical Sciences, Shandong University ) |
| Abstract: | Objective To investigate the protection of 2,5-bis （ 2, 5-dimethoxy-cinnamoyoxymethyl ） -3,6-dimethylpyrazine （ TMPC ） on oxidative damage to human umbilical vein endothelial cells （ HUVECs ）. Methods The HUVECs were damaged by hydrogen peroxide{ H202）, the protective effect of TMPC on endothelial cells was observed. Results TMPC protected the injured cells obviously, dcreased the malondialdehyde （ MDA } level induced by oxidative damage, increased the activity of superoxide disutase （ SOD ） , and reduced the calcium overload caused by the free calcium-induced in the oxidative damaged endothelial ceils. Conclusion TMPC has potent protection on oxidative damage,its potential mechanism relates to inhibiting the intracellular calcium overload and suppressing the generation of reactive oxygen species. |
| Keywords: | Tetramethylpyrazine derivatives Endothelial cells Oxidative damage Calcium overload |
| 本文献已被 维普 万方数据 等数据库收录！ | |