D-二聚体在肺栓塞诊断中的作用研究

目的 研究D-二聚体在诊断肺栓塞中的作用。方法 对80例临床可疑肺栓塞的患者进行回顾性分析，病人均行血D-二聚体测定和肺灌注扫描，通过肺扫描分为正常组、高可能性组和非诊断组，非诊断组再经肺动脉造影确定诊断。血D-二聚体测定采用乳胶凝集法。结果 共检出肺栓塞阳性41例，阴性39例，检出率51．2％。D-二聚体的敏感性和特异性分别为58．5％、51．3％，阳性预测值和阴性预测值分别为55．8％、54．5％。结论 D-二聚体测定尚不宜作为肺栓塞的筛选指标。

Study on the role of D-dimer test in diagnosis of pulmonary embolism

Objective To evaluate the role of D-dimer test in diagonsis of pulmonary embolism.Methods In a retrospective management study 80 patients with clinical suspicion of pulmonary embolism were investigated.A D-dimer test and lung perfusion scintigraphy were obtained in all patients.Lung scans were classified as normal,high probability for pulmonary embolism or non-diagnostic,followed by angiography in the cases with non-diagnostic lung scan result.D-dimer were determined by latex agglutination assay.Results 41 cases with positive and 39 cases with negative diagnosis of pulmonary embolism were achieved.The sensitivity,specificity,positive predictive value and negative predictive value of D-dimer were 58.5%,51.3%,55.8% and 54.5%,respectively.Conclusion D-dimer test is unsuitable to be used as a screening method of pulmonary embolism.