肺癌多药耐药机制的研究进展

肺癌化疗失败的主要原因是肿瘤细胞多药耐药（MDR）的产生。肺癌MDR的机制十分广泛，其中以ATP结合盒结构超家族成员参与耐药机制的研究较多。本文重点综述目前研究较多的P一糖蛋白、多药耐药相关蛋白、肺耐药相关蛋白和乳腺癌耐药蛋白与肺癌MDR的关系，并对其他肺癌MDR的发生机制如肿瘤细胞内解毒物质作用增强、药物作用靶点减少、DNA损伤修复功能增强及凋亡与抗凋亡机制的失衡作一简要介绍。

Research progress of mechanisms of multidrug resistance to lung cancer

Multidrug resistance (MDR) of lung cancer cells is a major cause of failure in chemotherapy.The multiple factors or mechanisms are involved in the chemoresistance of lung cancer cells. Most studies indicated that ABC(ATP binding cassette) transporter is important in the development of MDR. This paper provides a review on current advances of MDR mechanisms research in lung cancer such as P-glycoprotein, multidrug resistance protein, lung resistance protein and breast cancer resistance protein. Studies in strengthening effect of antitode in cancer cell, reduced targets, enhanced DNA repair function, unbalanced apoptosis are also introduced.