| α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies |
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| 作者姓名： | Alessandra Bigi Roberta Cascella Cristina Cecchi |
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| 作者单位： | Department of Experimental and Clinical Biomedical Sciences,Section of Biochemistry,University of Florence |
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| 摘 要： | The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system atrophy.In such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial cells.Growing expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the...
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