The voyage to healthy longevity: from experimental models to the ultimate goal |
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| Authors: | Globerson Amiela Barzilai Nir |
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| Affiliation: | a The Center for Multidisciplinary Research in Aging, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
b Departments of Medicine and Molecular Genetics, Institute for Aging Research, Diabetes Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA |
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| Abstract: | Understanding mechanisms underlying longevity, and endeavor towards the specific goals of alleviating frailty in old age, require a comprehensive approach that considers the various theoretical and experimental approaches, as well as compiling the data on humans. This logistic has underlined the program of the conference, and is reflected in the present special issue. Considerable volume of data now point to distinct genes that are associated with exceptional longevity in humans, as reflected from the articles in this volume. However, this symposium also highlighted non-genetic effects, including physical, mental and social activities, and elucidate the relevant underlying mechanisms. The symposium focused on understanding the basis of human longevity coupled to extended health-span and function into old age. |
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| Keywords: | Longevity genes Centenarian IGF-1 Growth hormone Apoptosis Skeletal tissues aging Neurodegeneration Lipids LDL HDL Stem cells |
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