Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis |
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| Authors: | Lorena Hernandez Marco AO Magalhaes Salvatore J Coniglio John S Condeelis Jeffrey E Segall |
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| Institution: | (1) Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA;(2) Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA |
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| Abstract: | Introduction CXCL12-CXCR4 signaling has been shown to play a role in breast cancer progression by enhancing tumor growth, angiogenesis,
triggering cancer cell invasion in vitro, and guiding cancer cells to their sites of metastasis. However, CXCR7 also binds to CXCL12 and has been recently found to
enhance lung and breast primary tumor growth, as well as metastasis formation. Our goal was to dissect the contributions of
CXCR4 and CXCR7 to the different steps of metastasis - in vivo invasion, intravasation and metastasis formation. |
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