| 4种标记蛋白抗体测定在鼻咽癌体检筛查及诊断中的应用 |
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| 引用本文： | 汪欣,赵素萍,吴旋,郑登滋. 4种标记蛋白抗体测定在鼻咽癌体检筛查及诊断中的应用[J]. 检验医学与临床, 2011, 8(21): 2563-2564. DOI: 10.3969/j.issn.1672-9455.2011.21.002 |
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| 作者姓名： | 汪欣 赵素萍 吴旋 郑登滋 |
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| 作者单位： | 1. 福建中医药大学附属第二人民医院,体检中心,福州,350003
2. 福建中医药大学附属第二人民医院,检验科,福州,350003 |
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| 摘 要： | 目的检测EB病毒Rta-IgG、病毒壳抗原(VCA-IgA)、Zta-IgA、核抗原(NA1-IgA)抗体在鼻咽癌血清中的表达水平,以及应用于体检中的最适指标。方法采用酶联免疫吸附试验(ELISA)分别检测健康体检者和鼻咽癌患者血清中的Rta-IgG、VCA-IgA、ZTA-IgA、NA1-IgA抗体水平,比较4项指标在鼻咽癌患者中的阳性预测值和健康体检者中的表达水平及阴性预测值。结果 20例确诊为鼻咽癌的患者检测结果数据可见,VCA-IgA阳性预测值为70%,NA1-IgA、Rta-IgG阳性预测值为85%,Zta-IgA阳性预测值为90%;对1 000例健康体检者4种标记蛋白抗体检测结果数据分析可见,Zta-IgA阴性预测值为83.3%,VCA-IgA阴性预测值为89.5%,Rta-IgG阴性预测值为91.9%,NA1-IgA阴性预测值为91.5%。结论在ELISA检测EB病毒4种标记蛋白抗体中,如果单独采用一种,则以Rta-IgG或NA1-IgA为佳,比较适合于健康体检人群的鼻咽癌体检筛查工作。如采用NA1-IgA、Zta-IgA、VCA-IgA或Zta-IgA、VCA-IgA、Rta-IgG 3项联合检测,则可提高阳性检出率。
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| 关 键 词： | 鼻咽癌 EB病毒 抗体 诊断 |
The Application of the detection of four protein antibody markers in screening and diagnosis of nasopharyngeal carcinoma |
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| WANG Xin,ZHAO Su-ping,WU Xuan,ZENG Deng-zi. The Application of the detection of four protein antibody markers in screening and diagnosis of nasopharyngeal carcinoma[J]. Laboratory Medicine and Clinic, 2011, 8(21): 2563-2564. DOI: 10.3969/j.issn.1672-9455.2011.21.002 |
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| Authors: | WANG Xin ZHAO Su-ping WU Xuan ZENG Deng-zi |
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| Affiliation: | WANG Xin1,ZHAO Su-ping2,WU Xuan1,ZENG Deng-zi2 |
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| Abstract: | Objective To detect the levels of antibodies Rta-IgG,VCA-IgA,Zta-IgA,NA1-IgA in EB virus in nasopharyngeal carcinoma,and to find the best indicator for the medical examination.Methods We detected the antibodies Rta-IgG,VCA-IgA,Zta-IgA,NA1-IgA in the healthy people and nasopharyngeal carcinoma patients by Elisa.We compared the predicted positive ratio of the four indicators in nasopharyngeal carcinoma patients and the predicted negative ratio in the healthy people.Results The predicted positive ratio of VCA-... |
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| Keywords: | nasopharyngeal carcinoma EB virus antibody diagnosis |
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