奥氮平与齐拉西酮治疗精神分裂症对照研究

目的探讨奥氮平与齐拉西酮治疗精神分裂症的疗效及安全性。方法选择60例精神分裂症患者,分别以奥氮平10～20mg/d(30例)及齐拉西酮80～140mg/d(30例)治疗。采用阳性与阴性症状量表(PANSS)、治疗中出现的药物副反应量表(TESS),评定疗效及不良反应。结果奥氮平组有效率、显效率分别为86.6%、66.6%,与齐拉西酮组(80.0%、63.3%)比较,差异无统计学意义;奥氮平组、齐拉西酮组的不良反应发生率分别为30%、27%(P>0.05)。结论奥氮平治疗精神分裂症,对阴性症状的疗效优于齐拉西酮(P<0.01)。两药不良反应发生率均较低。

Comparative study on effect of olanzapine and ziprasidone in treatment of schizophrenia

Objective To investigate the clinical efficacy and side effects of olanzapine and ziprasidone in treating schizophrenia.Methods Sixty patients were divided into olanzapine group(10~20 mg/d,n=30)and ziprasidone group(80~140 mg/d,n=30).The clinical effects and side effects were evaluated with positive and negative symptom scales(PANSS)and treatment emergent symptom scales(TESS).Results The effective rate and significant improved rate of olanzapine group were 86.6% and 66.6%;The effective rate and significant improved rate of ziprasidone were 80.0% and 63.3%.There was no significant difference in curative rates between the two groups(P>0.05).The side effects rates of olanzapine group and ziprasidone groups were 30.0% and 27%(P>0.05).Conclusion The effect of olanzapine is significantly better in treating negative symptom than ziprasidone(P<0.01),olanzapine has good effects on treating schizophrenia with less side effects.