交泰丸不同配比抗抑郁作用的实验研究

目的:研究不同配比交泰丸的抗抑郁作用.方法:雄性昆明小鼠按体重随机分为空白对照组、阳性药对照组(盐酸氟西汀7.5 mg·kg-1)及5种不同配比交泰丸高、低剂量组(黄连-肉桂=10∶1,1∶10,10∶0,0∶10,1∶1),共计12组.各组小鼠ig给药lh后采用小鼠悬尾实验(TST)、小鼠强迫游泳实验(FST)研究不同配比的交泰丸的抗抑郁作用.结果:在TST和FST中,与空白对照组比较,各给药组小鼠的不动时间均显著减少,其中以交泰丸中黄连与肉桂配比为10∶1和1∶10时对小鼠不动时间的影响最为明显,即在TST中,交泰丸黄连与肉桂配比为10∶1高、低剂量组时小鼠的不动时间分别为(69.8±18.1)s和(79.2±14.6)s,交泰丸黄连与肉桂配比为1∶10高、低剂量组时小鼠的不动时间分别为(69.5±21.7)s和(64.1±26.0)s；在FST中,交泰丸黄连与肉桂配比为10∶1高、低剂量组时小鼠的不动时间分别为(83.6±29.0)s和(72.9±37.7)s,交泰丸黄连与肉桂配比为1∶10高、低剂量组时小鼠的不动时间分别为(92.2±37.8)s和(71.9±35.9)s.交泰丸中黄连与肉桂配比为10∶1和1∶10组与空白组比较均有显著性差异(P＜0.05或P＜0.01),并且TST和FST的结果具有一致性(P＜0.01).结论:不同配比的交泰丸均具有抗抑郁的作用,但它们在抗抑郁作用强度上存在差异.

Study on the Antidepressant Effect of Jiaotai Pill with Different Proportions

Objective: To study the antidepressant effect of Jiaotai pill with different proportions. Method: Male Kunming mice were randomly divided into control group, fluoxetine (7.5 mg·kg^-1) group and five different proportions of Jiaotai pill in high and low dose groups (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1, 1: 10, 10: 0, 0: 10, 1: 1) according to body weight, togather 12 groups. The tail suspension test (TST) and the forced swimming test (FST) were used to observe the antidepressant effect of Jiaotai pillswith different proportions at 1 h after the administration (ig). Result: Compared with the control group, five different proportions of Jiaotai pill and fluoxetine (7.5 mg·kg^-1) reduced the immobility time both in the TST and FST, more obviously in Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1 and 1: 10). In the TST, the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1) in high and low dose groups was (69.8 ± 18.1) s and (79.2± 14.6) s, respectively; the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 1: 10) in high and low dose groups was (69.5 ± 21.7) s and (64.1 ± 26.0) s, respectively. In the FST, the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1) in high and low dose groups was (83.6 ± 29.0) s and (72.9± 37.7) s, respectively; the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 1: 10) in high and low dose groups was (92.2 ± 37.8) s and (71.9± 35.9) s, respectively. Compared with the control group, Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1 and 1: 10) show an obvious difference in TST and FST test(P<0.05 or P<0.01). The same results in the TST werefound in the FST (P <0.01). Conclusion: The results suggested that different proportions of Jiaotai pill performed antidepressant effect, while there may be a difference in intensity of the effect.