榼藤子生品和炮制品总皂苷体内抗肿瘤作用

目的:考察榼藤子生品和炮制品总皂苷体内抗肿瘤作用.方法:荷瘤小鼠随机分为8组,接种后第2天给药,连续10 d,模型对照组ig以等量生理盐水,阳性对照组腹腔注射顺铂3 mg· kg -1,低、中、高剂量榼藤子生品、炮制品总皂苷组分别ig 0.25,0.5,1 g·kg-1剂量.观察榼藤子总皂苷的肿瘤抑制作用；计算抑瘤率、胸腺指数、脾指数、肝脏指数；测定血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平.结果:榼藤子生品高、中、低剂量组的抑瘤率分别为58.86％,49.52％,43.45％,榼藤子炮制品高、中、低剂量组的抑瘤率分别为59.41％,48.81％,44.59％,榼藤子生品及炮制品总皂苷还能提升荷瘤小鼠血清SOD的活力,降低MDA水平.结论:榼藤子生品和炮制品总皂苷具有抗小鼠肿瘤作用,并可增强抗氧化能力.

Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of Entada phaseoloides

Objective: To study the anti-tumor action of total saponins from the crude and processed products of Entada phaseoloides in vivo. Method: Mice bearing transplanted tumor S180 were used to observe the effects of total saponins from E. phaseoloides;then inhibition ratio,thymus index,spleen index and liver index were calculated. The 1eve1 of superoxide dismutase (SOD) and malondialdehyde (MDA) was detected. Result: The crude and processed products E. phaseoloides saponins showed a significant anti-cancer activity on S180 implanted in mice, increased the level of SOD and reduced the content of MDA in blood serum in tumor-bearing mice. Conclution: The crude and processed products E. phaseoloides saponins have anti-tumor effects and anti oxidative capacity.