Fk-appaB在动脉粥样硬化中的作用

目的　研究体内基因多显性转录核因子 (NF kappaB)在动脉粥样硬化疾病中病变的动脉内皮细胞中表达的情况及意义。方法　采用免疫组织化学染色S P法检测 30例动脉粥样硬化病变动脉血管和 30例正常成年人动脉血管内皮细胞的NF kappaBP6 5蛋白 ,细胞间粘附分子 1(ICAM 1)和血管内皮细胞粘附分子 1(VCAM 1)的表达水平。结果　 (1)与正常动脉血管内皮细胞相比较 ,动脉粥样硬化病变动脉血管内皮细胞NF kappaBP6 5蛋白 ,ICAM 1以及VCAM 1表达水平均呈显著性增强 (P<0 0 0 1)。 (2 ) 6 0例动脉血管内皮细胞检测数据提示NF kappaB蛋白表达和ICAM 1表达呈直线回归关系 (b =0 80 2 ,P <0 0 0 1) ;NF kappaBP6 5蛋白表达和VCAM 1表达也呈直线回归关系 (b =0 711,P<0 0 0 1)。结论　NF kappaB的激活导致动脉粥样硬化患者体内ICAM 1和VCAM 1表达增强 ,加速了动脉粥样硬化病变过程

Effect of NF-kappa B in Atherosclerosis

Objective To investigate the significance of NF kappa B's expression in endothelial cell atherosclerotic peripheral artery. Methods Endothelial cells in arterial vascular vessels(one group deriving from the atherosclerosis patients; the other group deriving from the normal persons) are detected NF kappa BP65 protein, ICAM 1 and VCAM 1 expressions by immunohistochemistry staining. Results (1)The expression of NF kappa BP65 protein, ICAM 1 and VCAM 1 in endothelial cells is much more prominent than that in the normal persons ( P <0 001). (2)NF kappa BP65 protein and ICAM 1 expressions are related in linear regression (b=0 802, P <0 001), as well NF kappa B protein and VCAM 1 expressions (b=0 711, P <0 001). Conclusion The NF kappa B activation enhanced the ICAM 1 and VCAM 1 expressions, which accelerate the development of atherosclerosis in arterial vascular vessels.