自发性高血压大鼠心肌fas基因表达与左室肥厚关系探讨

目的 探讨自发性高血压大鼠（SHR）心肌fas表达及其与左室肥厚的关系。方法 自发性高血压大鼠（SHR）与正常血压大鼠各16号，尾套法测收缩压，逆转录-聚合酶边反应（RT-PCR）法测心肌fas mRNA表达。结果 与WKY相比，SHR心肌fas表达、左室重量指数(LVMI)均显著升高，且二者呈正相关。结论 自发性高血压大鼠早期心肌肥厚时心肌fas表达已经升高，可能参与后期心衰的发生。

Relations Between fas Gene Expression in Myocardium and Left Ventricular Hypertrophy in Spontaneous Hypertensive Rats

Objective To explore whether there are any relations between fas gene expression in myocardium and left ventricular hypertrophy(LVH) in spontaneous hypertensive rats(SHR). Methods Sixteen SHRs and WKYs were enrolled, systolic pressure was measured by tail-sleeve method. Fas mRNA expression in myocardium detected by RT-PCR method. Results Compared with WKY, the expression of fas in myocardium were significantly increased in SHR, and was positively correlated with left ventricular mass index(LVMI). Conclusions The fas mRNA expression in SHR increase during the early phase of myocardial hypertrophy and may play a important role in heart failure during late phase of SHR.