Brain norepinephrine and serotonin levels following REM sleep deprivation in the rat |
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| Authors: | Warren C. Stern Francis P. Miller Raymond H. Cox Roger P. Maickel |
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| Affiliation: | (1) Departments of Psychology and Pharmacology, Indiana University, 47401 Bloomington, Indiana;(2) Present address: Worcester Foundation for Experimental Biology, 01545 Shrewsbury, Massachusetts, USA |
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| Abstract: | Rats deprived of rapid eye movement (REM) sleep and stress controls showed no change in endogenous levels of norepinephrine and serotonin in the cerebral hemispheres, diencephalon, and brain stem. Following pargyline, the REM sleep deprived and stress control groups showed equally elevated norepinephrine and serotonin levels. These results suggest that enhanced biogenic amine synthesis following REM sleep deprivation is due to non specific stress rather than to loss of REM sleep per se. |
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| Keywords: | REM Sleep Deprivation Stress Norepinephrine Serotonin |
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