~(18)F-FDG PET/CT扫描早期诊断重症急性胰腺炎继发感染的探讨

目的探讨氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(~(18 )F-FDG PET/CT)在早期诊断重症急性胰腺炎(SAP)继发感染的评估价值。方法分别构建两种细菌(ATCC 25922和ATCC 25923)的SAP SD大鼠感染组模型,并以生理盐水构建对照组模型。分别在建模后0、1、3h检测动物全血细胞计数和血清淀粉酶,建模后3h行~(18)F-FDG PET/CT显像,并进行生物学分布、HE染色和Gram染色等验证PET显像结果。结果~(18 )F-FDG PET/CT显像提示,两种细菌感染组大鼠模型均显示胰腺部位的放射性浓聚灶;大肠埃希菌组、金黄色葡萄球菌组和生理盐水组靶(胰腺)/非靶(肌肉)比值(SUV)分别为4.22±0.61、4.32±1.21、2.26±0.35,两种细菌感染组模型动物SUV值无统计学差异(P0.05),大肠埃希菌感染组模型与对照组模型比较有统计学差异(P0.01)。生物学分布结果与PET显像结果一致。结论~(18)F-FDG PET/CT可以作为早期诊断SAP继发感染的检测方法。

Value of 18F-FDG PET/CT in the early diagnosis of secondary infection of severe acute pancreatitis

ObjectiveTo evaluate the value of 18F FDG PET/CT in the early diagnosis of secondary infection of severe acute pancreatitis (SAP).MethodsInfection group models of SAP SD rats were constructed with two types of bacteria (ATCC 25922 and ATCC 25923), control group model was constructed with saline solution. Complete blood cell count and serum amylase were measured at hour 0， 1， and 3 after modeling. After modeling for 3 hours，18F FDG PET/CT imaging was performed, then biological distribution, HE staining, and gram staining were performed to verify the results of PET imaging.Results18F FDG PET/CT imaging showed that rat models of two types of bacteria infection groups both showed radioactivity concentration in pancreas; target(pancreas) and non target (muscle) ratios(SUV) of Escherichia coli group, Staphylococcus aureus group, and saline group were 4.22+0.61，4.32+1.21，and 2.26+0.35 respectively. There was no statistical difference in the SUV of model animals between two types of bacteria infection group (P>0.05). The model of Escherichia coli infection group was statistically different from that of the control group model (P<0.01). Biological distribution was consistent with the result of PET imaging.Conclusion18F FDG PET/CT can be used as a detection method for early diagnosis of secondary infection of SAP.