| 不同血液透析方式对维持性血液透析患者肾性贫血的影响 |
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| 引用本文： | 岳华,徐世茹,刘红,侯佳,阿迪拉,伊力夏提,赵红娟,赵志刚,崔如晨.不同血液透析方式对维持性血液透析患者肾性贫血的影响[J].国外医学：泌尿系统分册,2013(6):761-764. |
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| 作者姓名： | 岳华 徐世茹 刘红 侯佳 阿迪拉 伊力夏提 赵红娟 赵志刚 崔如晨 |
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| 作者单位： | 乌鲁木齐新疆维吾尔自治区人民医院肾病科,新疆830001 |
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| 基金项目： | 新疆维吾尔自治区科技支疆项目课题资助,项目编号：201191161） |
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| 摘 要： | 目的 探讨低通量血液透析（LFHD）与高通量血液透析（HFHD）对维持性血液透析（MHD）患者贫血状态的影响.方法 选择2011年5月至2012年11月在新疆自治区人民医院血液净化中心行MHD治疗的慢性肾脏病（CKD）5期患者共50例,随机分为LFHD组和HFHD组各25例,观察两组患者首次透析前和治疗3个月后（透析前）的血红蛋白（Hb）、尿素氮（BUN）、全段甲状旁腺激素（iPTH）、白细胞介素-6（IL-6）、血清C反应蛋白（CRP）及血清β2微球蛋白（β2 MG）的变化并进行分析比较.结果 LFHD组与HFHD组首次透析前各项指标比较无统计学差异（P＞0.05）；LFHD组治疗前后比较对BUN、iPTH、IL-6、的清除无差异（P＞0.05）,对CRP、β2 MG清除有差异（P＜0.01）,对Hb提升有差异（P＜0.01）；HFHD组治疗前后比较对BUN清除无差异（P＞0.05）,对iPTH、IL-6、CRP、β2 MG的清除有差异（P＜0.05）,对Hb提升有显著差异（P＜0.01）；LFHD组与HFHD组之间治疗后比较对BUN清除无差异（P＞0.05）,对iPTH、IL-6、CRP、β2 MG的清除有差异（P＜0.05）,对Hb提升有显著差异（P＜0.01）.结论 HFHD能够有效清除中分子毒素和微炎症细胞因子,改善透析患者的贫血状态.
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| 关 键 词： | 贫血 肾透析 |
Effect of different hemodialysis on maintenance hemodialysis patient with renal anemia |
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| Institution: | YUE Hua(Research Institution of Nephrology,the People＇s Hospital of the Xinjiang Uygur Autonomous Region, Urumqi 830001 ,China) XU Shi-ru(Research Institution of Nephrology,the People＇s Hospital of the Xinjiang Uygur Autonomous Region, Urumqi 830001 ,China) LIU Hong(Research Institution of Nephrology,the People＇s Hospital of the Xinjiang Uygur Autonomous Region, Urumqi 830001 ,China) |
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| Abstract: | Objectives Discusses low flux hemodialysis （LFHD） with high flux hemodialysis （HFHD）state of anemia in patients with maintenance hemodialysis （MHD） effect.Methods Choice Chronic kidney disease（CKD） stage 5 patients a total of 50 cases in the Xinjiang autonomous region people＇s hospital of MHD blood purification center,which came from May of 2011 to November of 2012.Were randomly divided into LFHD and HFHD group 25 cases each,Observe for the first time through two groups of patients before and after treatment in 3 months,such as：the hemoglobin（Hb）,urea nitrogen（BUN）,segment parathyroid hormone（iPTH）,interleukin-6 （il-6）,c-reactive protein（CRP） and serum beta 2 microglobulin（β2 MG） changes were analyzed and compared.Results LFHD group and HFHD dialysis before comparing the indicators for the first time no statistical difference（P〉 0.05） ; LFHD group before and after treatment comparison of BUN,iPTH,il-6,no difference （P 〉 0.05）,the CRP,β2 MG removal difference（P 〈0.01）,Hb ascend have differences（P 〈0.01）;HFHD group is cleared to BUN no difference before and after the treatment（P 〉0.05）,to iPTH,il-6,CRP,β2 MG removal difference（P 〈0.05）,the Hb ascend there is significant difference（P 〈0.01）;LFHD group compared with HFHD group after treatment between the BUN no difference（P 〉0.05）,to iPTH,il-6,CRP,β2 MG removal difference（P 〈0.05）,for Hb ascend significant differences（P 〈 0.01）.Conclusions HFHD can effectively remove the middle molecular toxins and inflammatory cytokines,to improve the anemia status of dialysis patients. |
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| Keywords: | Anemia Renal Dialysis |
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