不同血液净化方式对慢性肾功能衰竭的疗效分析

目的 比较不同血液净化方式对慢性肾功能衰竭（chronic renal failure,CRF）的疗效.方法 选取2005年至2011年期间本院收治的65例需要行血液净化治疗的CRF患者,随机分为3组,其中24例予血液透析联合血液灌流（Hemodialysis and hemoperfusion,HD＋ HP）、21例予血液透析（Hemodialysis,HD）、20例予腹膜透析（Peritoneal d（i）alysis,PD）,比较3组治疗前后各项临床指标的变化.结果 对比每组治疗前后的血尿素氮（BUN）、血肌酐（Cr）、收缩压（SBP）、舒张压（DBP）、血红蛋白（Hb）、二氧化碳结合力（CO2CP）,差异均有统计学意义（P＜0.05）；对比HD＋HP组治疗前后的β2-微球蛋白（β2-MG）差异有统计学意义（P＜0.05）,HD和PD两组组内对比治疗前后的β2-MG差异均无统计学意义（P＞0.05）.结论 HD＋ HP、HD和PD这三种血液净化方式治疗CRF均能有效改善患者的BUN、Cr、SBP、DBP、Hb、CO2 CP,而且HD＋ HP对于β2-MG的清除有着更加显著的效果.

Efficacy analysis of different blood purification techniques on chronic renal failure

Objectives To analyse the efficacy of different blood purification techniques on chronic renal failure（CRF）. Methods Totally 65 CRF patients who need to be given blood purification treatment in our hospi tal from 2005 to 2011 were selected and randomly divided into three group,including 24cases in hemodialysis and he moperfusion （ HD ＋ HP） group,21 cases in hemodialysis （ HD ） group and 20cases in peritoneal dialysis （ PD ） group. Compare the change of clinical indicators after the treatment of blood purification. Results Compared with the clinical indicators including BUN, Cr, SBP, DBP, Hb and CO2 CP of each group before and after treatment,there were significant differences （ P 〈 0. 05 ）. Moreover, there was significant difference in β2 - MG after treatment in HD ＋ HP group（ P 〈0.05） while there were no significant difference in β2 - MG after treatment in HD group and PD group（ P 〉 0.05 ）. Conclusions HD ＋ HP, HD and PD these three blood purification treatment can effectively improve the clinical indicators of CRF patients, including BUN, Cr, SBP, DBP, Hb and CO2CP. Moreover, HD ＋ HP has a more significant effect on clearing β2 -MG.