Acute enhancement of spinal cord synaptosomal (Na + K)-ATPase activity in cats following intravenous methylprednisolone |
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Authors: | J. Mark Braughler Edward D. Hall |
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Abstract: | The acute intravenous administration of high doses of methylprednisolone sodium succinate (15–90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed. |
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Keywords: | spinal cord (Na+ + K+)-ATPase methylprednisolone |
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