老年冠心病抑郁与卒中后抑郁的心血管危险因子临床对比研究

目的对比研究冠心病抑郁与卒中后抑郁的心血管危险因子。方法收集门诊及住院60岁以上的冠心病患者68例,其中符合抑郁症诊断标准的33例;缺血性脑卒中患者61例,伴抑郁31例。检测患者的血压、血清学指标、空腹和餐后血糖(BS)、血脂(TG、TC、LDL)、同型半胱氨酸(Hcy)、肝肾功能及心血管危险性基因ApoE。结果 (1)冠心病组及缺血脑卒中组合并高血压病、糖尿病、高脂血症、高HCY血症及ApoE(+)比较,差异无统计学意义(P>0.05);(2)老年冠心病抑郁者高血压发生率高于非抑郁者,卒中后抑郁者与非抑郁者心血管危险因子阳性率相比较,高血压和ApoE(+)方面差异均有统计学意义(P<0.05)。结论高血压病可促进老年冠心病患者和缺血性卒中患者抑郁的发生;ApoE(+)与抑郁的关系可能与其对认知的影响相关。

A clinical comparative study of cardiovascular risk factor between aged coronary heart disease depression and post-stroke depremion

Objective To compare cardiovascular risk factors between coronary heart disease depression and post-stroke depression. Methods Sixty-eight gerontal inpatient or outpatient （ age 〉 60 year） were recruited,including 33 diagnosed depression, 61 ischemic stroke, 31 accompanied stress. Blood pressure, serological index, fasting blood glucose, postprandial blood glucose, blood lipid （TG,TC, and LDL）, homocysteine, liver and kidney function, and ApoE, a cardiovascular risk related gene, were measured. Results （ l ） There was no statistical significance between in the rates of accompanied hypertension, diabetes, hyperlipoidemia, high homocysteic acid, or ApoE between coronary heart disease group and ischemic stroke. （2）The rz~e of accompanied hypertension in aged depressed coronary heart disease group was higher than in non-depressed group. There were significant different in the rate of hypertension and ApoE between depressed stroke and non-depressed stroke. Conclusions It seems that hypertension might promote the onset of depression of aged coronary heart disease and ischemic strnke patients, and the relationship between ApoE （ ＋ ） （ and depression might be related to their influence on recognition.