同步放疗联合介入化疗治疗中晚期子宫颈癌的临床观察

 目的　比较吡柔比星（THP）、5-氟尿嘧啶（5-Fu）联合顺铂（DDP）介入化疗联合放疗与单纯放疗治疗中晚期子宫颈癌的疗效和不良反应。方法　将48例经病理确诊的ⅡB～Ⅳ期子宫颈癌患者按随机数字表法分为同步放疗及介入化疗组（25例）和单纯放疗组（23例），两组放疗剂量相同，同步放化疗组在放疗前后予以髂内动脉局部介入灌注化疗，THP 30～40 mg、5-Fu 0.50～0.75 g、DDP 40～ 60 mg，28 d为1个周期，共 3～4个周期 。对比两组的治疗效果及相关不良反应。结果　同步放疗及介入化疗组有效率为92.0 %（23／25），3年生存率80.0 %（20／25）。单纯放疗组有效率为69.6 %（16／23）， 3年生存率为52.2 %（12／23），两组差异有统计学意义（均P＜0.05）。两组相关不良反应发生率之间差异无统计学意义（均P＞0.05），经对症处理后可耐受，为可逆的。结论　同步放疗联合介入化疗治疗中、晚期子宫颈癌可显著提高患者有效率及生存率，不良反应与单纯放疗相比无明显增加。

Response of concurrent radiation combined with interventional artery infusion chemotherapy in advanced cervical carcinoma

Objective To investigate the clinical curative effects and side effects of concurrent radiotherapy combined with interventional artery infusion chemotherapy in advanced cervical carcinoma. Methods 48 patients with advanced cervical carcinoma were randomly divided into two groups including concurrent radiotherapy combied with interventional artery infusion chemotherapy group （25 patients） and radiotherapy group （23 patients）. Each patient in the concurrent radiotherapy combined with interventional artery infusion chemotherapy group was given THP, DDP and 5-Fu, repeatedly every 28 days, total 3-4 cycles. Radiotherapy was given at the same time. Results The effective rates of the concurrent radiotherapy combined with interventional artery infusion chemotherapy group and radiotherapy group were 92.0 % （23/25） and 69.6 % （16/23）, respectively. The overall 3 year survival rates for the patients in concurrent radiotherapy combined with interventional artery infusion chemotherapy group and radiotherapy group were 80.0 % （20/25） and 52.2 % （12/23）, respectively, and there was statistically significant between the 2 groups （all P 〈 0.05）. No more side effects were found in the concurrent radiotherapy combined interventional artery infusion chemotherapy group （P 〉 0.05）. Conclusion Concurrent radiotherapy combined with interventional artery infusion chemotherapy in advanced cervical carcinoma can increase short term therapeutic effect and improve the survival rate of the patients without more side effects.