人类组织激肽释放酶10在子宫内膜腺癌组织中的表达及其与雌激素、孕激素受体表达的相关性

 目的　检测人类组织激肽释放酶10（KLK10）在不同子宫内膜组织中的表达，并探讨其与雌激素受体（ER）和孕激素受体（PR）之间的相关性。方法　应用免疫组织化学方法测定KLK10在12例正常子宫内膜、19例子宫内膜增生症、34例子宫内膜腺癌组织中的表达，并分析KLK10与ER、PR之间的相关性。结果　KLK10在正常子宫内膜组织、子宫内膜增生症组织、子宫内膜腺癌组织中阳性率分别为91.7 %（11／12）、78.9 %（15／19）、38.2 %（13／34），两两比较差异均有统计学意义（均P＜0.05）。KLK10在Ⅰ、Ⅱ、Ⅲ期子宫内膜腺癌组织中表达阳性率分别为64.3 %（9／14）、30.0 %（3／10）、10.0 %（1／10），两两比较差异均有统计学意义（均P＜0.05）。KLK10在高、中、低分化的内膜腺癌组织中表达阳性率分别为66.7 %（8／12）、33.3 %（4／12）、10.0 %（1／10），两两比较差异均有统计学意义（均P＜0.05）。34例子宫内膜腺癌组织中，KLK10表达阳性率为38.2 %，ER、PR表达阳性率为67.6 %、55.9 %，KLK10与ER、PR表达均呈正相关（χ2＝0.448，P＜0.01）。结论　KLK10表达缺失或下调可能促进子宫内膜腺癌的发生和发展。KLK10在子宫内膜腺癌组织中表达降低，ER、PR的表达也降低，呈正相关。KLK10阳性者预后相对较好。

Expression of KLK10 in endometrioid adenocarcinoma and its relationship with ER and PR

Objective To evaluate the expression of human kallikrein10 （KLK10） in different endometrioid tissues and analyse the relationship of KLK10 with ER and PR in endometrioid adenoeareinoma. Methods The expression of KLK10 protein in 12 normal endometria,19 endometrial hyperplasia and 34 endometrial carcinoma were detected by immunohistochemistry. The correlations of the expression of KLK10 protein, ER and PR were analyzed. Results The expression of KLK10 in stage Ⅰ , Ⅱ and m were 64.3 % （9/14）, 30.0 % （3/10）, 10.0 % （1/10）, and the difference was statistically significant （P 〈 0.05）. The expression of KLK10 in endometrial carcinoma, normal endometria, endometrial hyperplasia were 66.7 % （8/12）, 33.3 % （4/12）, 10.0 % （1/10）, and the difference was statistically significant （P 〈 0.05）. The expression of KLK10 in G1, G2, G3 were 66.7 %, 33.3 %, 10.0 %, and the difference was statistically significant （P 〈 0.05）. The positive rate of KLK10 expression was 38.2 % and the positive rates of ER and PR expression were 67.6 % and 55.9 %, respectively, in 34 endometrial carcinoma. The expression of KLK10 was positively correlated with ER and PR expression （χ2 = 0.448, P 〈 0.01）. Conclusion Absence or down-regulated expression of KLKIO may play an important role in the formation and development of endometrioid adenocareinoma. The low expression of KLK10 is correlated with low expression of ER and PR in endometrioid adenocareinoma. The positive expression of KLKO0, ER and PR predicts a better prognosis.