阿托伐他汀抗家兔内膜损伤后动脉粥样硬化的实验研究

目的探讨阿托伐他汀抗动脉粥样硬化的作用。方法将29只新西兰白兔随机分为正常组7例、病理组7例、用药5周组7例及用药9周组8例。实验前后抽血测定血脂全套,主动脉标本用作普通光镜、透射电镜及斑块面积检查。结果阿托伐他汀显著降低胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C),升高高密度脂蛋白胆固醇(HDL-C),组织病理学检查显示用药组血管内膜厚度、内膜中泡沫细胞、平滑肌细胞(SMC)明显减少,未见合成型SMC,用药9周组与病理组相比斑块面积减小。结论阿托伐他汀具有明显的抗动脉粥样硬化的作用。

Experimental study of effect of atorvastatin on atherosclerosis in an rabbit intimal injury model

Objective To investigate the effect of atorvastatin on atherosclerosis.Methods Twenty-nine healthy New Zealand white rabbits were randomly separated into 4 groups: normal group (n=7),pathological group(n=7)(2.5 mg·kg-1·d-1)and 9 week atorvastatin treated group (n=8)( 2.5 mg·kg-1·d-1).Total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C)and triglyceride(TG)were assayed at the onset and the end of the study.The arteries were processed for hematoxylin-eosin staining, scanning electron microscopy and measurement of plaque area.Results Atorvastatin reduced serum TC,LDL-C,and TG,while elevated serum HDL-C.Histopathologic examination showed the treated group had a remarkably decreased intimal thickness,intimal foam cells and smooth muscle cells (SMC),but without synthetic SMC.The plaque area was reduced in 9 week treated group(P<0.05).Conclusion Atorvastatin has antiatherogenic effect.