Immunohistochemical study of oral keratoses including lichen planus |
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Authors: | W D Robertson D Wray |
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Institution: | Department of Oral Medicine &Oral Pathology, University of Edinburgh, Scotland |
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Abstract: | Biopsies of non-ulcerated oral mucosa from 13 patients with oral lichen planus and 12 patients with leukoplakia were immunohistochemically stained using monoclonal antibodies to pan T, pan B, T helper and T suppressor/cytotoxic cells and the stained lymphocytes enumerated using an image analyser. The results show the preponderance of T cells infiltrating both oral lichen planus and leukoplakia. The T helper: T suppressor/cytotoxic cell ratio was the same (1:2) for both oral lichen planus and leukoplakia. A similar proportion of T suppressor/cytotoxic cells was found infiltrating the epithelium. These data indicate that T cell subset analysis is of no value in distinguishing oral lichen planus from other oral keratoses. |
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Keywords: | immunohistochemistry leukoplakia oral lichen planus |
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