| Effects of Compound Salviae Miltiorrhizae Injection on Metabolism of Phosphoinosititides in Myocardial Ischemia |
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| 引用本文： | Yue-yu Tao,Song-duo Guo,Hui-zheng Chen,Hua Hu,Bu-feng Lu,Yu-lan Yan,You-ming Lu. Effects of Compound Salviae Miltiorrhizae Injection on Metabolism of Phosphoinosititides in Myocardial Ischemia[J]. 中国结合医学杂志, 1995, 1(4): 288-290. DOI: 10.1007/BF02940701 |
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| 作者姓名： | Yue-yu Tao Song-duo Guo Hui-zheng Chen Hua Hu Bu-feng Lu Yu-lan Yan You-ming Lu |
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| 作者单位： | Tao Yue-yu (陶月玉) ; Guo Song-duo(郭松铎); Chen Hui-zheng (陈惠珍)and Hu Hua (胡华)(Nanjing 414 Hospital of Navy，Nanjing 210015)Lu Bu-feng (卢步峰) ; Yan Yu-lan(严玉兰) and Lu You-ming (鲁友明)(Nanjing Research Center of Neuro-biology of Navy) |
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| 摘 要： | ＥｆｆｅｃｔｓｏｔＣｏｍｐｏｕｎｄＳａｌｖｉａｅＭｉｌｔｉｏｒｒｈｉｚａｅＩｎｊｅｃｔｉｏｎｏｎＭｅｔａｂｏｌｉｓｍｏｆＰｈｏｓｐｈｏｉｎｏｓｉｔｉｔｉｄｅｓｉｎＭｙｏｃａｒｄｉａｌＩｓｃｈｅｍｉａＴａｏＹｕｅ－ｙｕ（陶月玉）；ＧｕｏＳｏｎｇ－ｄｕｏ...
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Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia |
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| Yue-yu Tao,Song-duo Guo,Hui-zheng Chen,Hua Hu,Bu-feng Lu,Yu-lan Yan and You-ming Lu. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia[J]. Chinese journal of integrative medicine, 1995, 1(4): 288-290. DOI: 10.1007/BF02940701 |
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| Authors: | Yue-yu Tao Song-duo Guo Hui-zheng Chen Hua Hu Bu-feng Lu Yu-lan Yan You-ming Lu |
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| Affiliation: | 1. Nanjing 414 Hospital of Navy, 210015, Nanjing
2. Nanjing Research Center of Neuro-biology of Navy, China
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| Abstract: | Using the model of acute myocardial ischemia in rats formed by ligation of the descending an-terior branch of the left coronary artery, this study showed some effects of compound Salviae miltiorrhizae in-jection ( CSMI) on metabolism of phosphoinositide in myocardial ischemia. The results of the experimentshowed that after 10 minutes of acute ischemia, the function of myocardial messangers ot phosphoinositide in-creased, and the levels of phosphatidylinositol-4, 5-biphosphate ( PIP2 ) and inositol-1, 4, 5-trisphosphate(IP3 ) were obviously higher than those of the non-ischemia control groups ( P < 0. 01 , n = 7) . CSMI (2 glkgbody weight) could markediy inhibit myocardial PIP2 and IP3, whose levels became lower than those of theischemia control groups ( P < 0 . 01 , n = 7 ) . |
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| Keywords: | Myocardial ischemia phophoinositides compound Salviae miltiorrhizae injection |
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