肿瘤相关物质群水平测定对恶性肿瘤疗效及预后的判断价值

目的 :探讨血清中肿瘤相关物质群 (TSGF)水平对恶性肿瘤疗效及预后判断的价值。方法 :采用比色法测定 135 7例恶性肿瘤患者 (治疗前 4 6 4例 ,治疗显效 5 0 8例 ,治疗无效 93例 ,复发 2 92例 )和134例健康对照的血清TSGF水平。结果 :各种肿瘤患者血清TSGF水平均明显高于健康对照 (P <0 0 1) ,与治疗前相比较 ,治疗有效组的TSGF水平明显下降 ,而复发组的TSGF水平明显上升 (P <0 0 1)。检测TSGF对治疗前恶性肿瘤的敏感度为 5 6 0 % ,特异度为 97 0 % ,阳性预测值为 98 5 % ,阴性预测值为 38 9% ;而对复发转移的敏感度为 6 9 9% ,特异度为 89 4 % ,阴性预测值为 85 2 %。结论 :血清TSGF水平测定是恶性肿瘤诊断、疗效及预后判断的重要指标 ,对复发转移有良好预测价值

Clinical Value of TSGF in the Predicting of Response to Treatment and Prognosis in Malignant Tumors

Objective To investigate the clinical significance of tumor supplies group of factors (TSGF) for the response to treatment and prognosis of malignant tumors.Methods The serum levels of TSGF were assayed by spectrophotometry in 1 357 patients with carcinomas (464 initiated tumors,508 cases of objective responsed to treatment,93 non responders and 292 patients with recurrent tumors) and 134 healthy controls.Results The positive rates of TSGF value were 42 2%-88 9% at the borderline of 64 U/mL for initiated tumors.Compared with pretreatment group,the TSGF level decreased profoundly in responders( P <0 01),and obvious elevated in elapsed patients( P <0 01).At the level of 64 U/mL,TSGF indicated any cancers with a specificity of 97 0%,a sensitivity of 56 0%,a positive predictive value of 98 5%,and a negative predictive value of 38 9%.Moreover,TSGF assay was able to exclude distant metastasis and recurrence with a negative predictive value of 85 2%,a sensitivity of 69 9%,and a specificity of 89 4%.Conclusions The TSGF is an important parameter on diagnosis,monitoring response to treatment and prognosis of carcinomas,especially for predicting of recurrence or metastasis. China J Cancer Prev Treat,2003,10(3):263-265