| 硝基(芳亚胺基)二乙基硫代硫酸钠和硝基苯丙氮酸衍生物的合成和放射增敏作用 |
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| 引用本文： | 刘汇辛,胡璧,李政,糜福顺,沈瑜. 硝基(芳亚胺基)二乙基硫代硫酸钠和硝基苯丙氮酸衍生物的合成和放射增敏作用[J]. 药学学报, 1992, 27(8): 632-637 |
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| 作者姓名： | 刘汇辛 胡璧 李政 糜福顺 沈瑜 |
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| 作者单位： | 中国医学科学院放射医学研究所,天津300192;*中国医学科学院肿瘤研究所,北京100021 |
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| 摘 要： | A series of compounds was synthesized, these compounds were tested for Hela-S3cells in vitro for radiosensitizing activity. Five of them are 2,2′- (arylimino)-diethyl-sodium thio-sulfate and two of them are phenylalanine derivatives. Most of them showed various degrees of ra-diosensitizing activity. Among them, SER of L07 was 1.89 at 3 mmol, and had low cytotoxicity toHela-S3 cells;ID50 was 18.8 mmol. The relationship between radiosensitizing effects and chemicalstructure was discussed. It offers a base for further exploration of selectively hypoxic cell radiosens-itizers.
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| 关 键 词： | 放射增敏药 2,2′-(芳亚胺基)二乙基硫代硫酸钠 苯丙氨酸衍生物 |
| 收稿时间： | 1991-12-10 |
SYNTHESIS AND RADIOSENSITIZING ACTIVITY OF NITROARYLIMINO-DIETHYL-SODIUM THIOSULFATE AND NITRO PHENYLALANINE DERIVATIVES |
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| HX Liu,B Hu,Z Li,FS Mi,Y Shen. SYNTHESIS AND RADIOSENSITIZING ACTIVITY OF NITROARYLIMINO-DIETHYL-SODIUM THIOSULFATE AND NITRO PHENYLALANINE DERIVATIVES[J]. Acta pharmaceutica Sinica, 1992, 27(8): 632-637 |
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| Authors: | HX Liu B Hu Z Li FS Mi Y Shen |
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| Affiliation: | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin. |
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| Abstract: | A series of compounds was synthesized, these compounds were tested for Hela-S3 cells in vitro for radiosensitizing activity. Five of them are 2,2'-(arylimino)-diethyl-sodium thiosulfate and two of them are phenylalanine derivatives. Most of them showed various degrees of radiosensitizing activity. Among them, SER of L07 was 1.89 at 3 mmol, and had low cytotoxicity to Hela-S3 cells, ID50 was 18.8 mmol. The relationship between radiosensitizing effects and chemical structure was discussed. It offers a base for further exploration of selectively hypoxic cell radiosensitizers. |
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| Keywords: | 2, 2'--(Arylimino)--diethyl--sodium thiosulfate Phenylalanine derivatives Radiosensitizer |
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