参龙汤对D-半乳糖诱导衰老大鼠学习记忆功能的影响

目的探讨参龙汤对D-半乳糖拟衰老大鼠学习记忆能力的影响。方法Wistar大鼠40只随机分为对照组、参龙汤1组（大剂量）、参龙汤2组（中剂量）、参龙汤3组（小剂量）、模型组。采用D-半乳糖诱导的脑老化大鼠动物模型,用通道式水迷宫测定大鼠学习记忆能力的变化;测定药物处理后各组大鼠脑组织超氧化物歧化酶（SOD）活性、丙二醛（MDA）浓度的变化。结果与正常对照组相比,模型组大鼠游泳时间延长、游泳正确次数降低（均P〈0.05）。应用参龙汤大剂量处理6周后,大鼠的游泳时间降低,正确次数增加（P〈0.05）;同时大剂量参龙汤组还能提高D-半乳糖诱导的脑老化大鼠脑组织中SOD的活性,降低丙二醛浓度（P〈0.05）。结论参龙汤能改善D-半乳糖诱导的脑老化大鼠学习记忆能力,提高脑组织中SOD的活性,降低丙二醛的浓度。

Effect of Shenlongtang on Learning and Memory of Aging Rats Induced with D-Glalactose

Objective To investigate the effect of Shenlongtang on the function of learning and memory of aging rats induced with D-glalactose. Methods 40 Wistar rats were dividied into control group, model group, treating group 1 (large dosage), treating group 2 (medial dosage), treating group 3 (lower dosage). The aging models were induced with D-galactose. The memory function was tested with passageway water maze. The activity of superoxide dismutase (SOD) and content of malodialdehyde (MDA) was measured. Results In the D-galactose model rats, the swimming time was prolonged significantly, and the correct number was decreased significantly compared with normal group (P<0.05). After Six weeks treating with Shenlongtang, the swimming time significantly shortened and the correct number increased significantly in large dosage group compared with the model group (P<0.05). The activity of SOD increased and the content of MDA decreased in large dosage group compared with that in the model group (P<0.05).Conclusion Shenlongtang can improve the learning and memory function of aging rats induced with D-glalactose and resist lipid peroxide in brain tissue.